Protein kinase C modulators. C. indolactam structural-types with

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 62, 514183, 536 187, 536 53, 540452, 540460, A61K 31395, A61K 3140, C07D48700, C07D48706

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active

059624981

ABSTRACT:
Compounds having anti-inflammatory, anti-viral, protein kinase C-modulatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class, each bearing an additional 6-atom chain connecting positions 3 and 4 to form a fused 9-membered ring. This invention is exemplified by 9-deshydroxymethyl-9-carboxyindolactam V.

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