Inhibition of tumor necrosis factor .alpha.

Details Inhibition of tumor necrosis factor .alpha. Inhibition of tumor necrosis factor .alpha.

1998-03-19

1999-10-05

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514311, 514334, A61K 3144

Patent

active

059624787

ABSTRACT:
In a preferred embodiment, a method for the inhibition of the synthesis and release of tumor necrosis factor from various cells, comprising: administering to a human or other mammal an effective dose of one or more pharmaceutical substances selected from the group consisting of N-substituted 2(1H)pyridones, N-substituted 3(1H)pyridones, and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3839346 (1974-10-01), Gadekar
patent: 3974281 (1976-08-01), Gardekar
patent: 4042699 (1977-08-01), Gardekar
patent: 5310562 (1994-05-01), Margolin
patent: 5518729 (1996-05-01), Margolin
patent: 5641751 (1997-06-01), Heavner
patent: 5716632 (1998-02-01), Margolin

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