Tricyclic compounds in treating hyperalgesic conditions and NIDD

Details Tricyclic compounds in treating hyperalgesic conditions and NIDD Tricyclic compounds in treating hyperalgesic conditions and NIDD

1996-03-28

1999-10-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514213, 5142245, 5142298, 514250, 514290, 540522, 540547, 540557, 544101, 544349, 546 79, A01N 4346, C07D48700, C07D26534, C07D22106

Patent

active

059624493

ABSTRACT:
The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

REFERENCES:
patent: 2860137 (1958-11-01), Cusic et al.
patent: 5256409 (1993-10-01), Blincko
Adamczyk et. al., "A Facile Synthetic Route to Hydroxy...", Org. Prep. & Proc. Int., vol. 23(3), 1991, pp. 365-372.
Berkow et. al., "The Merck Manual of Diagnosis and Therapy," 16.sup.th Edition, 1992, pp. 1418-1419.
Adamczyk et. al., "Characterization of Protein-Hapten Conjugates..." Bioconjugate Chem. vol.5(6), 1994, pp. 631-635.

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