Human kallikrein

Details Human kallikrein Human kallikrein

1997-03-26

1999-10-05

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435226, 4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 950, C12N 1500, C12N 120, C07H 2104

Patent

active

059623004

ABSTRACT:
The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.

REFERENCES:
Hansson, L. et al., "Cloning, Expression, and Charaterization of Stratum Corneum Chyotryptic Enzyme", J. Biol. Chem., 269: 19420-19426 (1994) (GI 521214) (GI 532504).
Riegman, P.H.J. et al., "Characterization of the Human Kallikrein Locus", Genomics, 14:6-11 (1992) (GI 186652) (GI 186653).
Bridon, D.P. et al., "Structual Comparison of Prostate-Specific Antigen And Human Glandular Kallikrein Using Molecular Modeling", Urology, 45: 801-806 (1995).
Fukushima, D. et al., "Nucleotide Sequence of Cloned cDNA for Human Pancreatic Kallikrein", Biochemistry, 24: 8037-8043 (1985).
Fahnestock, M. et al., "Characterization of Kallikrein cDNAs from the African Rodent Mastomys", DNA and Cell Biology, 13: 293-300 (1994) (GI 55526) (GI 55527).
Hansson et al. (1994) Cloning, Expression, and Characterization of Stratum Corneum Chymotryptic Enzyme: A Skin-Specific Human Serine Proteinase. J. Biol. Chem. 269(30): 19420-19426.
Hillier et al. zd55e11.s1 Soares Fetal Heart NbHH19W Homo sapiens cDNA Clone 344588 3' Similar to PIR:A53968 Serine Protease SCCE Precursor-Human. EST-STS Accession No. W73140. Public Availability Date Jun. 14, 1996.

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