Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-12-20
1999-10-05
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 4352523, 435455, 435471, 536 237, 536 243, C12N 121, C12N 510, C12N 1531
Patent
active
059622598
ABSTRACT:
Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
REFERENCES:
patent: 5476781 (1995-12-01), Moyer et al.
patent: 5602014 (1997-02-01), Mizumura et al.
patent: 5606022 (1997-02-01), Rasmussen
Benjamini et al., Immunology: A Short Course, second ed., Wiley-Liss, New York, p. 40, 1992.
Daniel et al., Virology 202:540-549, 1994.
Ishizuka et al. A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp. Journal of Bacteriology. vol. 174, No. 23, pp. 7585-7594, Dec. 1992.
Lee et al. Phosphate regulon in members of the family Enterobacteriaceae: comparison of the phoB-phoR operons of Escherichia coli, Shigella dysenteriae, and Klebsiella pneumoniae. Journal of Bacteriology. vol. 171, No. 12, pp. 6593-6599, Dec. 1989.
Makino et al. Nucleotide sequence of the phoB gene, the positive regulatory gene for the phosphate regulon of Escherichia coli K12. Journal of Molecular Biology. vol. 190, pp. 37-44, 1986.
Sambrook et al. MOlecular Cloning: A Laboratory Manual, 2d ed. CSHLP, Cold Spring Harbor, NY. Chapters 9 and 11, 1989.
Scholten et al. The pho regulon of Shigella flexneri. Molecular Miobiology. vol. 15, No. 2, pp. 247-254, 1995.
Stock et al. Signal Transduction in bacteria. Nature. vol. 344, pp. 395-400, Mar. 29, 1990.
Stock et al., Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiological Reviews. vol. 53, No. 4, pp. 450-490, Dec. 1989.
Wells. Additivity of mutational Effects in Proteins. Biochemistry. vol. 29, No. 37, pp. 8509-8517, Sep. 18, 1990.
George et al. Current Methods in sequence comparison and analysis. Macromolecular Sequencing and Synthesis. Alan R Liss, Inc. pp. 127-149, 1988.
Zhang et al. A bacillus subtilis bglA gene encoding phospho-.beta.-glucosidase is inducible and closely linked to a NADH dehydrogenase-encoding gene. Gene. vol. 140, pp. 85-90, 1994.
Kessler et al. Plant Molecular Biology. vol. 18, No. 4, p. 177, 1992.
Seki et al., "Cloning and Nucleotide Sequence of phoP, the Regulatory Gene for Alkaline Phosphatase and Phosphodiesterase in Bacillus subtilis", Journal of Bacteriology, 169, No. 7, pp. 2913-2916(1987).
Hulett et al., "Sequential Action of Two-Component Genetic Switches Regulates the PHO Regulon in Bacillus subtilis", Journal of Bacteriology, 176, No. 5, pp. 1348-1358.
Bayles et al. "The use of degenerate, sensor gene-specific, oligodeoxyribonucleotide primers to amplify DNA fragments from Staphylococcus aureus", Gene, 123, pp. 99-103 (1993).
Volz et al., "Stuctural Conversation in the CheY Superfamily", Biochemistry, 32, No. 44, pp. 11741-11753 (1993).
Feher et al., .sup.1 H, .sup.15 N, and .sup.13 C backbone chemical shift assignments, secondary structures, and magnesium-binding characteristics of the Bacillus subtilis response regluator, SpoOF, determined by heteronuclear high-resolution NMR, Protein Science, 4, pp. 1801-1814 (1995).
Volkman et al., Three-Dimensional Solution Structure of the N-Terminal Receiver Domain of NTRC, Biochemistry, 34, pp. 1413-1424 (1995).
Swanson, et al., "Histidine and aspartate phosphorylation: two-component systems and the limits of homology", TIBS, 19, pp. 485-491 (1994).
Stock, et al., "Three-dimensional structure of CheY the response regulator of bacterial chemotaxis", Nature, 337, pp. 745-749 (1989).
Volz, et al., "Crystal Structure of Escherichia coli CheY Refined at 1.7-a Resolution", The Journal of Biological Chemsitry, 266, No. 23, pp. 15511-15519 (1991).
Matsumura, P., et al., , J. Bacteriol., 160, pp. 36-41 (1984).
Turgay, et al., The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis, DNA Sequence-The Journal of Sequencing and Mapping, (1995), vol. 5: pp. 283-290.
Hodgson John Edward
Wallis Nicola Gail
Gimmi Edward R.
Jackson Arthur E.
Kemmerer Elizabeth
King William T.
SmithKline Beecham Plc
LandOfFree
Response regulator polynucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Response regulator polynucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Response regulator polynucleotides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1170319