Radiohalogenated thienylethylamine derivatives for evaluating lo

Details Radiohalogenated thienylethylamine derivatives for evaluating lo Radiohalogenated thienylethylamine derivatives for evaluating lo

1988-12-22

1990-02-13

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

549 74, 424 9, A61K 4902, C07D33312

Patent

active

049005391

ABSTRACT:
Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation or regional blood flow by radioimaging of the brain.

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Fernandez-Tome, et al., "Relation Between Locomotor Hyperactivity Induced by P-Chloroamphetamine in Rats and Uptake of .sup.3 H-Dopamine," Arch, Farmacol Toxicol 1979, 5(3), 169-171.
David E. Kuhl et al., "Quantifying Local Cerebral Blood Flow by N-Isopropyl-p-[123]Iodamphetamine (IMP) Tomography," Oct. 15, 1981, pp. 196-203.
Hank F. Kung, et al., "A New Brain Perfusion Imaging Agent:[1-123]HIPDM:N,N,N'-Trimethyl-N'-[2-Hydroxy-3-Methyl-5-Iodobenzyl]-1 ,3-Propanediamine," Jun. 3, 1982, pp. 66-72.

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