2-Amino-1,4-dihydropyridine derivatives

Details 2-Amino-1,4-dihydropyridine derivatives 2-Amino-1,4-dihydropyridine derivatives

1974-11-25

1976-11-02

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948F, 2602948G, 2602949, 2602955R, 2602955B, C07D21355

Patent

active

039897087

ABSTRACT:
2-Amino-1,4-dihydropyridines bearing an ester carbonyl function in the 3-position, being optionally substituted by lower alkyl in the 5-position, and being substituted in the 4- and 6-positions by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-chlorophenyl)-1,4-dihydropyridine-3 carboxylic acid ethyl ester is a representative embodiment, are prepared through condensation of an .alpha.-B-unsaturated ketone and an amidine.

REFERENCES:
patent: 3775422 (1973-11-01), Bossert et al.
patent: 3799934 (1974-03-01), Meyer et al.
patent: 3799936 (1974-03-01), Meyer et al.

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