Hybrid cell line for producing monoclonal antibody to a human ea

Details Hybrid cell line for producing monoclonal antibody to a human ea Hybrid cell line for producing monoclonal antibody to a human ea

1982-10-04

1986-11-25

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

935104, 935110, 4351722, 435948, 435 68, 424 85, C12N 500, C12N 1500, C12P 2100, A61K 39359

Patent

active

046249257

ABSTRACT:
Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

REFERENCES:
patent: 4364934 (1982-12-01), Kung et al.
patent: 4381292 (1983-04-01), Bieber et al.
patent: 4434156 (1984-02-01), Trowbridge
McMichael et al, "A Human Thymocyte Antigen Defined by a Hybrid Myeloma Monoclonal Antibody", European Journal of Immunology, 9, p. 205-210 (1979).

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