Influenza vaccine production in liquid cell culture

Details Influenza vaccine production in liquid cell culture Influenza vaccine production in liquid cell culture

1987-02-18

1990-02-13

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435236, 435237, 435238, 435239, A61K 3912, C12N 700, C12N 702, C12N 704

Patent

active

RE0331643

ABSTRACT:
Infectivity and replication of influenza viruses in successive numbers of cells of the same liquid cell culture is assured by including a protein hydrolyzing enzyme in the culture during virus incubation. Technique overcomes "one-step growth cycle" of virus and allows commercial influenza vaccine production from liquid cell cultures instead of from more costly embryonated chicken eggs. Resulting vaccine is thus substantially free of egg proteins.

REFERENCES:
patent: 3060094 (1962-10-01), Dutcher et al.
patent: 3616203 (1971-10-01), Brown
patent: 3655871 (1972-04-01), Werner
patent: 3933585 (1976-01-01), McAleer et al.
patent: 3959074 (1976-05-01), Miller et al.
patent: 3965258 (1976-06-01), McAleer et al.
patent: 4070453 (1978-01-01), Bordt et al.
patent: 4080258 (1978-03-01), McAleer et al.
patent: 4205131 (1980-05-01), Almeida
Klenk et al., Virology 68, 426-439 (1975).
Lazarowitz et al., (I), Virology, 68, 440-454 (1975).
Lazarowitz et al., II, Virology 52, 199-212 (1973).
Effect of Trypsin on Reproduction of Type 4 Parainfluenza Virus in Vero Cell Cultures Under Fluid Overlay--Morimoto et al.-pp. 1-11, Japan. J. Med. Sci. Biol., 23, 1970.
Effect of Trypsin on Viral Susceptibility of Vero Cell Cultures-Cercopithecus Kidney Line-Itoh et al.-pp. 227-235, 1970, Japan J. Med. Sci. Biol., 23, 1970.
Genetic Recombination for Antigenic Markers of Antigenically Different Strains of Influenza B Virus-Tobita et al.--pp. 347-352, Journal of Virology-Feb. 1974.
The Use of a Continuous Cell Line for the Isolation of Influenza Viruses-Davies et al.-pp. 991-993, Bulletin of the World Health Organization 56(6) (1978).
Identification of the Defective Genes in Three Mutant Groups of Influenza Virus-Ritchey et al.-pp. 1196-1204, Journal of Virology, 21(3) (1977).
Activation of Influenza A Viruses by Trypsin Treatment-Klenk et al., pp. 426-430-Virology 68, (1975).

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