Cysteic acid and homocysteic acid analogues of methotrexate and

Organic compounds -- part of the class 532-570 series – Organic compounds – Plural nitrogens bonded directly to the pteridine ring system

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C07D47508

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active

044905297

ABSTRACT:
Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin having antitumor activity and low toxicity are soluble in water at a physiological pH ranging from 7.2-7.5.

REFERENCES:
patent: 2742468 (1956-04-01), Brockman et al.
Seeger et al., J. Am. Chem. Soc., vol. 71, pp. 1753-1758 (1949).

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