Open chain analogues of retinoic acid

Details Open chain analogues of retinoic acid Open chain analogues of retinoic acid

1983-05-11

1984-12-25

Waltz, Thomas A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2604105, 2604106, 2604109, 260413, 260404, 424314, 424318, 424320, 424324, 2604109V, C07C 5703, C07C 69587, C07C103133, A61K 3123

Patent

active

044904142

ABSTRACT:
Open ring retinoic acid analogues and 2Z isomers of the formula ##STR1## where X is ##STR2## and R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy with 0 or 1 hydroxy or alkoxy-monosubstituted phenoxy or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, alkyl, or aryl and R.sup.2 is alkyl or aryl are disclosed. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

REFERENCES:
patent: 3746730 (1973-07-01), Marbet
patent: 3781314 (1973-12-01), Bollag et al.
patent: 4107193 (1978-08-01), Kijima et al.
patent: 4147708 (1979-04-01), Manchand

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