Process for the preparation of amino acetic acid esters with a t

Details Process for the preparation of amino acetic acid esters with a t Process for the preparation of amino acetic acid esters with a t

1999-07-09

2000-08-08

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560121, 560123, 560124, 560125, C07C22900, C07C 6974

Patent

active

061004243

ABSTRACT:
Aminoacetic acid esters of formula I in which R.sup.1, R.sup.2 and R.sup.3 are identical or different hydrocarbon radicals, or any two of these radicals form a carbon ring with the carbon atom to which they are attached and R.sup.4 is hydrogen or an alkyl radical having 1-4 carbon atoms, are prepared by reacting an .alpha.-substituted malonic acid monoamide ester of formula II ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings above, by the Hofmann degradation reaction, with a hypohalite in an amount of up to 1.5 equivalents in an aqueous-basic medium containing base in an amount of 0.8-1.5 equivalents per mol. of starting malonic acid monoamide ester II.

REFERENCES:
patent: 5831119 (1998-11-01), Bauer et al.
Miyazawa, T. et al "Synthesis of tert-Leucine" Konan Univ. Sci. Ser. No. 23 pp 51-54, 1979.
Streitwieser, A. et al "Introduction to Organic Chemistry" Macmillan: New York, p 801, 1976.

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