Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Cellular products or processes of preparing a cellular...
Patent
1998-10-02
2000-08-08
Cooney, Jr., John M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Cellular products or processes of preparing a cellular...
521 62, 521 63, 521 64, 521141, 521146, 521147, 521149, 521150, 523218, 424489, C08J 926
Patent
active
061003069
ABSTRACT:
The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.
REFERENCES:
patent: 3255127 (1966-06-01), von Bonin
patent: 3460972 (1969-08-01), Nuck
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3822224 (1974-07-01), Gillan et al.
patent: 3879314 (1975-04-01), Gunning et al.
patent: 3891577 (1975-06-01), Kershaw et al.
patent: 3923704 (1975-12-01), Gunning et al.
patent: 3933579 (1976-01-01), Kershaw et al.
patent: 3943063 (1976-03-01), Morishita et al.
patent: 3988508 (1976-10-01), Lissant
patent: 4137380 (1979-01-01), Gunning et al.
patent: 4321332 (1982-03-01), Beresford et al.
patent: 4384975 (1983-05-01), Fong
patent: 4401456 (1983-08-01), Connick, Jr.
patent: 4522953 (1985-06-01), Barby et al.
patent: 4536521 (1985-08-01), Haq
patent: 4611014 (1986-09-01), Jomes et al.
patent: 4612334 (1986-09-01), Jones et al.
patent: 4629742 (1986-12-01), Brady et al.
patent: 4690825 (1987-09-01), Won
patent: 4741872 (1988-05-01), De Luca et al.
patent: 4742086 (1988-05-01), Masamizu et al.
patent: 4775655 (1988-10-01), Edwards et al.
patent: 4788225 (1988-11-01), Edwards et al.
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4873091 (1989-10-01), Jankower et al.
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4965289 (1990-10-01), Sherrington et al.
patent: 4985468 (1991-01-01), Elmes et al.
patent: 5073365 (1991-12-01), Katz et al.
patent: 5135740 (1992-08-01), Katz et al.
patent: 5135872 (1992-08-01), Pouletty et al.
patent: 5145675 (1992-09-01), Won et al.
patent: 5147345 (1992-09-01), Young et al.
patent: 5149720 (1992-09-01), DesMarais et al.
patent: 5168104 (1992-12-01), Li et al.
patent: 5189070 (1993-02-01), Brownscombe et al.
patent: 5200433 (1993-04-01), Beshouri
patent: 5246714 (1993-09-01), Dahlinder et al.
patent: 5252619 (1993-10-01), Brownscombe et al.
patent: 5268097 (1993-12-01), Girot et al.
patent: 5306733 (1994-04-01), Adamski et al.
patent: 5306734 (1994-04-01), Bass et al.
patent: 5316774 (1994-05-01), Eury et al.
patent: 5318554 (1994-06-01), Young et al.
patent: 5331015 (1994-07-01), DesMarais et al.
patent: 5393528 (1995-02-01), Staab
patent: 5422123 (1995-06-01), Conte et al.
patent: 5425265 (1995-06-01), Jaisinghani
patent: 5458890 (1995-10-01), Williford et al.
patent: 5583162 (1996-12-01), Li et al.
patent: 5653922 (1997-08-01), Li et al.
patent: 5760097 (1998-06-01), Li et al.
patent: 5840293 (1998-11-01), Nacht et al.
patent: 5863957 (1999-01-01), Li et al.
patent: 5871722 (1999-02-01), Nacht et al.
Arshady, R., "Suspension, Emulsion, and Dispersion Polymerization: A Methodological Survey," 270 Colloid & Polymer Science 717-732 (1992).
Atyabi, F. et al., "Controlled Drug Release From Coated Floating Ion Exchange Resin Beads," 42 Journal of Controlled Release 25-28 (1996).
Brooke, D. and Washkuhn, R., "Zero-Order Drug Delivery System: Theory and Preliminary Testing," 66(2) Journal of Pharmaceutical Sciences 159-162 (Feb. 1977).
Crotts, G., and Park, T., "Preparation of Porous and Nonporous Biodegradable Polymeric Hollos Microspheres," 35 Journal of Controlled Release 91-105 (1995).
DeLuca, P. et al., "Biodegradable Polyesters for Drug and Polypeptide Delivery" 203rd National Meeting of the American Chemical Society 53-79 (Apr. 5-10, 1992) in Polymeric Delivery Systems, El-Nokaly, M. et al, eds.
Even, W. and Gregory, D., "Emulsion-Derived Foams: Preparation, Properties, and Application," MRS Bulletin 29-33 (Apr. 1994).
Hainey, P. et al., "Synthesis and Ultrastructural Studies of Styrene-Divinylbenzene Polyhipe Polymers," 24 Macromolecules 117-121 (1991).
Harland, R. et al. "A Model of Dissolution-Controlled, Diffusional Drug Release From Non-Swellable Polymeric Microspheres," 7 Journal of Controlled Release 207-215 (1988).
Herrmann, J. and Bodmeier, R., "The Effect of Particle Microstructure on the Somatostatin Release From Poly (Lactide) Microspheres Prepared by a W/O/W Solvent Evaporation Method," 36 Journal of Controlled Release 63-71 (1995).
Hsieh, D. et al. "Zero-Order Controlled-Release Polymer Matrices for Micro- and Macromolecules," 72(1) Journal of Pharmaceutical Sciences 17-22 (Jan. 1983).
Jeyanthi, R. et al., "Effect of Solvent Removal Technique On the Matrix Characteristics of Polylactide/Glycolide Microspheres for Peptide Delivery," 38 Journal of Controlled Release 235-244 (1996).
Kissel, T. et al. "Parenteral Protein Delivery Systems Using Biodegradable Polyesters of ABA Block Structure, Containing Hydrophobic Poly (lactide-co-glycolide) A Blocks and Hydrophilic Poly (ethylene oxide) B Blocks," 39 Journal of Controlled Release 315-326 (1996).
Koyama, Y. et al., "Receptor-Mediated Absorption of High Molecular Weight Dextrans From Intestinal Tract," 41 Journal of Controlled Release 171-176 (1996).
Kyo, M. et al., "Effects of Preparation Conditions of Cisplatin-Loaded Microspheres on the In Vitro Release," 35 Journal of Controlled Release 73-82 (1995).
Langer, R., "Polymer Systems For Controlled Release of Macromolecules, Immobilized Enzyme Medical Bioreactors, and Tissue Engineering," 19 Advances in Chemical Engineering 1-50 (1994).
Lee, D. et al., "High Density BHK Culture Using Porous Microcarriers," Production of Biologicals from Animal Cell Culture, Butterworth-Heinemann 480-487 (1992).
Lee, D. et al., "Polystyrene Macroporous Bead Support for Mammalian Cell Culture," 665 Annals New York Academy of Sciences 137-145 (1992).
Mathlowitz, E. et al., "Biologically Erodable Microspheres As Potential Oral Drug Delivery Systems," 386 Nature 410-414 (Mar. 1997).
McGee, J. et al., "Zero Order Release of Protein From Poly (D,L-lactide-co-glycolide) Microparticles Prepared Using a Modified Phase Separation Technique," 34 Journal of Controlled Release 77-86 (1995).
Santus, G. and Baker, R. "Osmotic Drug Delivery: A Review of the Patent Literature," 35 Journal of Controlled Release 1-21 (1995).
Small, P. and Sherrington, D., "Design and Application of a New Rigid Support for High Efficiency Continuous-Flow Peptide Synthesis," 21 Journal of the Chemical Society 1589-1591 (1989).
Tijssen, P., "Nature of Protein-Plastic Interaction," Practice & Theory of Enzyme Immunoassays 298-314 (Elsevier 1985).
Williams, J., "Toroidal Microstructures from Water-in-Oil Emulsions," 4 Langmuir 44-49 (1988).
Williams, J. and Wrobleski, D., "Spatial Distribution of the Phases in Water-in-Oil Emulsions. Open and Closed Microcellular Foams from Cross-Linked Polystyrene," 4 Langmuir 656-662 (1987).
Youxin, L. and Kissel, T. "Synthesis and Properties of Biodegradable ABA Triblock Copolymers Consisting of Poly (L-lactic acid) or Poly (L-lact-co-glycolic acid) A-Blocks Attached to Central Poly (Oxyethylene) B-Blocks," 27 Journal of Controlled Release 247-257 (1993).
Benson James R.
Kitagawa Naotaka
Li Nai-Hong
Biopore Corporation
Cooney Jr. John M.
Haliday Emily M.
Maher David W.
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