Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

Filed on

1998-12-22

Date issued

2000-08-08

Examiner

Kight, John

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

548195, 548192, 548200, 546209, 5462697, 514326, 514342, 514365, A61K 31426, C07D27738

Type

Patent

Status

active

Patent number

061002828

Description

ABSTRACT:
Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R.sup.1, R.sup.2 and R.sup.3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of cell and accordingly influence cell--cell and cell-matrix interactions. These compounds can be used in the form of pharmaceutical preparations for the control or prevention of neoplasms, tumor metastasing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure, as well as infection caused by viruses, bacteria or fungi.

REFERENCES:
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patent: 5000775 (1991-03-01), Grabiak et al.
patent: 5430024 (1995-07-01), Alig et al.
patent: 5532258 (1996-07-01), Katsura et al.
Schnur et al., J. Med. Chem., 34:914-918 (1991).
Plazzi et al., IL Farmaco, 44(11):1011-1030 (1989).
Barton et al., J.C.S. Perkin I, 159-164 (1982).
Chemical Abstracts, vol. 127, No. 2, No. 17675n, (1994).

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