Enantioselective preparation of optically pure albuterol

Details Enantioselective preparation of optically pure albuterol Enantioselective preparation of optically pure albuterol

1994-05-23

1995-03-21

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560 42, 564304, 564356, C07C20968

Patent

active

053997654

ABSTRACT:
The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoate using ditoluoyltartaric acid.

REFERENCES:
Hartley et al. "Absolute Configuration of the Optical Isomers of Salbutamol" J. Med. Chem. 14, 895-896 (Apr. 17, 1971).
Hopkins "Salbutamol" Drugs of the Future IV 629-633 (May 2, 1979).
Floyd et al. "The Oxidation of Acetophenones to Arylglyoxals with Aqueous Hydrobromic Acid in Dimethyl Sulfoxide" J. Org. Chem. 50, 5022-5027 (Jun. 1, 1985).
Collin et al. "Saligenin Analogs of Sympathomimetic Catecholamines" Chemistry Dept., Allen and Hanburys Ltd. (Apr. 13, 1970).

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