Treatment of HIV

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 18, 514408, A61K 3700, A61K 3140

Patent

active

061002348

ABSTRACT:
A method for increasing immune responses of a human patient infected with HIV, involving contacting the T-cells, in vitro or in vivo, with an organic compound at a concentration effective to cause T-cell proliferation, but below an amount that causes detectable cytotoxicity.

REFERENCES:
patent: 4318904 (1982-03-01), Shaw et al.
patent: 4443609 (1984-04-01), Oude Alink et al.
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4582821 (1986-04-01), Kettner et al.
patent: 4636492 (1987-01-01), Kettner et al.
patent: 4644055 (1987-02-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
patent: 4935493 (1990-06-01), Bachovchin et al.
patent: 4963655 (1990-10-01), Kinder et al.
patent: 5093477 (1992-03-01), Molling et al.
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5215926 (1993-06-01), Etchells, III et al.
patent: 5242904 (1993-09-01), Kettner et al.
patent: 5250720 (1993-10-01), Kettner et al.
patent: 5288707 (1994-02-01), Metternich
patent: 5296604 (1994-03-01), Hanko et al.
patent: 5378624 (1995-01-01), Berenson et al.
patent: 5384410 (1995-01-01), Kettner et al.
patent: 5444049 (1995-08-01), de Nanteuil et al.
patent: 5462928 (1995-10-01), Bachovchin et al.
patent: 5506130 (1996-04-01), Peterson et al.
patent: 5527923 (1996-06-01), Klingler et al.
patent: 5543396 (1996-08-01), Powers et al.
patent: 5554728 (1996-09-01), Basava et al.
patent: 5635386 (1997-06-01), Palsson et al.
patent: 5635387 (1997-06-01), Fei et al.
patent: 5646043 (1997-07-01), Emerson et al.
Colowick, S., et al., "Methods in Enzymology", pp. 220-225.
Cordes, E., et al., "Transition States for Hydrolysis of Acetals, Ketals Glycosides, and Glycosylamines", Chapter 11, pp. 429-465.
Thompson, R., "Use of Peptide Aldehydes to Generate Transition-State Analogs of Elastase", Biochemistry, (1973), 12:1:47-51.
Baugh, R., et al., "Proteinases and Tumor Invasion", (1980), 165:157-179.
Bodanszky, M., "Principles of Peptide Synthesis", Springer-Verlag, (1984), vol. 16.
Bodanszky, M., "The Practice of Peptide Synthesis", Springer-Verlag, (1984), vol. 21.
Matteson, D., et al., "Synthesis and Properties of Pinanediol .alpha.-Amido Boronic Esters" Organometallics, (1984), 3:1284-1288.
Powers, C., et al., "Elastase Inhibitors for Treatment of Emphysema--NHLBI Workship Summary" US Dept. of Health and Human Services, (1985), 1097-1100.
Yoshimoto, T., et al., "Comparison of Inhibitory Effects of Prolinal-Containing Peptide Derivatives on Prolyl . . . ", (1985), 98:975-979.
Kettner, C.A., et al., "Kinetic Properties of the Binding of Alpha-Lytic Protease to Peptide Boronic Acids", Biochemistry, (1988), 27:7682-7688.
Tam, J.P., "Synthetic Peptide Vaccine Design: Synthesis and Properties of a High-Density Multiple Antigenic Peptide System", Proc Natl Acad Sci U S A, (1988), 85:5409-5413.
Bailey, P.D., "An Introduction to Pepetide Chemistry", Wiley Publishers, (1990), 1-81.
Kettner, C.A. and Shenvi, A.B., "Peptide Boronic Acid Inhibitors of Trypsin-Like Proteases, Their Preparation and Use As Anticoagulants and Inflammation Inhibitors", Chemical Abstracts, (1990), 112:80 (91790c).
Bachovchin, W.W., et al., "Inhibition of IGA1 Proteinases From Neisseria Gonorrhoeae and Hemophilus Influenzae by Peptide Prolyl Boronic Acids", J Biol Chem, (1990), 265:3738-3743.
Kinder D.H., et al., "Analogues of Carbamyl Aspartate as Inhibitors of Dihydroorotase: Preparation of Boronic Acid Transition-State Analogues and a Zinc Chelator Carbamylhomocysteine", J Med Chem, (1990), 33:819-823.
Flentke, G.R., et al., "Inhibition of Dipeptidyl Aminopeptidase IV (DP-IV) by XAA-Boropro Dipeptides and Use of These Inhibitors to Examine the Role of DP-IV in T-Cell Function", Proc Natl Acad Sci U S A, (1991), 88:1556-1559.
Schon, E., et al., "Dipeptidyl Peptidase IV in the Immune System", Biol Chem Hoppe-Seyler, (1991), 372:305-311.
Kubota, T., et al., "Involvement of Dipeptidyl Peptidase IV in an In Vivo Immune Response", Clin Exp Immunol, (1992), 89:192-197.
Gutheil, W.G., et al., "Separation of L-Pro-DL-Boropro Into Its Component Diastereomers and Kinetic Analysis of Their Inhibition of Dipeptidyl Peptidase IV. A New Method for the Analysis of Slow, Tight-Binding Inhibition", Biochemistry, (1993), 32:8723-8731.
Kelly, T.A., et al., "Immunosuppressive Boronic Acid Dipeptides: Correlation Between Conformation and Activity", J Am Chem Soc, (1993), 115:12637-12638.
Songyang, Z., et al., "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell, (1993), 72:767-778.
Subramanyam, M., et al., "Mechanism of HIV-1 Tat Induced Inhibition of Antigen-Specific T Cell Responsiveness", J Immunol, (1993), 150:2544-2553.
Demuth, H.U., et al., "Design of (Omega-N-(O-Acyl)Hydroxy Amid) Aminodicarboxylic Acid Pyrrolidides as Potent Inhibitors of Proline-Specific Peptidases", FEBS Lett, (1993), 320:23-27.
Janeway, C., et al., "Immunobiology--The Immune System in Health and Disease", Current Biology LTD, (1994), Chapter 12, pp. 1-35.
Brady, L., and Dodson, G., "Reflections on a Peptide", Nature, (1994), 368:692-693.
Nicola, N, et al., "Guidebook to Cytokines and Their Receptors", Sambrook and Tooze Publications, (1994), pp. 1-257.
Perstorp Biotec Company, "Molecular Biology Catalog", (1994).
Jameson, B.A., et al., "A Rationally Designed CD4 Analogue Inhibits Experimental Allergic Encephalomyelitis", Nature, (1994), 368:744-746. Abstract.
Mosmann, T.R., "Cytokine Patterns During the Progression to AIDS", Science, (1994), 265:193-194.
Seed, B., "Making Agonists of Antagonists", Chemistry & Biology, (1994), 1:125-129.
Austin, D.J., et al., "Proximity Versus Allostery; The Role of Regulated Protein Dimerization in Biology", Chemistry & Biology, (1994), 1:131-136.
Sudmeier, J.L., et al., "Solution Structures of Active and Inactive Forms of the DP IV (CD26) Inhibitor Pro-Boropro Determimed by NMR Spectroscopy", Biochemistry, (1994), 33:12427-12438.
Kubota, T., et al., "Dipeptidyl Peptidase IV (DP IV) Activity in Serum and on Lymphocytes of MRL/ Mp-Ipr/Ipr Mice Correlates with Disease Onset", Clin Exp Immunol, (1994), 96:292-296.
Snow, R.J., et al., "Studies on Proline Boronic Acid Dipeptide Inhibitors of Dipeptidyl Peptidase IV: Identification of a Cyclic Species Containing a B-N Bond", J. Am. Chem Soc, (1994), 116:10860-10869.
Gunther, U.L., et al., "Solution Structures of the DP IV (CD26) Inhibitor Val-BoroPro Determined by NMR Spectroscopy", Magnetic Resonance in Chem, (1995), 33:959-970.
Subramanyam, M., et al., "CD26, At-Cell Accessory Molecule Induction of Antigen-Specific Immune-Suppression by Inactivation of CD26: A Clue to the AIDS Paradox?", in Dipeptidyl Peptidase IV(CD26) in Metabolism and Immune Response, (1995), Ed. B. Fleischer: 155-162.
Schmitz T, et al., "Potentiation of the Immune Response in HIV-1+ Individuals", J Clin Invest, (1996), 97:1545-1549.
Aguila, H.L., et al., "From Stem Cells to Lymphocytes: Biology and Transplantation", Immune Rev, (1997), 157:13-40.
Dupont, B., "Immunology of Hematopoietic Stem Cell Transplantation: A Brief Review of Its History", Immun Rev, (1997), 157:5-12.
Bodansky, M., "Peptide Chemistry, A Practical Textbook", Springer-Verlag, (1988) 1-9.
Boros, L.G., et al., "Fluoroolefin Peptide Isosteres-Tools for Controlling Peptide Conformations", Tetrahedron Letters, (1994), 35:6033-6036.
Goodman, M., and Chorev, M., "On the Concept of Linear Modified Retro-Peptide Structures", Accounts of Chemical Research, (1979), 12:1-7.
Guichard, G., et al., Partially Modified Retro-Inverso Pseudopeptides as Non-Natural Ligands for the Human Class I Histocompatibility Molecule HLA-A2, J Med Chem, (1996), 39:2030-2039.
Jardetzky, T.S., et al., Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed With Superantigen, Nature, (1994), 368:711-718.
Zimmerman, D.H., et al., "A New Approach to T-Cell Activation: Natural and Synthetic Conjugates Capable of Activating T Cells", Vaccine Res, (1996), 5:91-102.
Zimmerman, D.H., et al., "Immunization With Peptide Heteroconjugates Primes a T Helper Cell . . . " Vaccine Res. (1996), 5:103-118.
Welch, J.T., and Lin J., Fluoroolefin Containing Dipeptide Isoteres as

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of HIV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of HIV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of HIV will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1150212

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.