Cycloalkylthiazoles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548201, 548204, 548205, 548202, C07D27722

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active

053997026

ABSTRACT:
Compounds of the formula: ##STR1## wherein the substituents are as defined herein, and enantiomers, diastereomers, racemates and salts with pharmaceutically acceptable bases, antagonize LTD.sub.4 action and thus, are useful in treating bronchial asthma, pulmonary anaphylaxis, cystic fibrosis, chronic bronchitis, bronchiectasis, respiratory distress syndrome and pulmonary oedema.

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patent: 4933328 (1990-06-01), Curtze et al.
patent: 5001140 (1991-03-01), Field et al.
Tetrahedron vol. 44, No. 7, 1988 pp. 2021-2031.
Liebigs Annalen der Chemie No. 4, 1981 pp. 623-632.
Jpn.J.Pharmacol (1989) 50(1) 37-46.
Chemical Abstracts vol.114:6492f Preparation of 2-styrylthiazole and benzothiazole derivatives as leukotriene antagonists (1991).

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