Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1991-12-16

1993-11-09

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 8, 5625724, 562523, 562590, 562598, 560176, C11C 104, A61K 3120

Patent

active

052604659

ABSTRACT:
This invention relates to pharmaceutical compounds of structural formula (I): ##STR1## and compositions and methods of treatment utilizing these compounds to inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 4112241 (1978-09-01), Okano et al.
patent: 4410719 (1983-10-01), Fischer et al.
patent: 4650896 (1987-03-01), Fischer et al.
patent: 4658069 (1987-04-01), Hanes et al.
patent: 4835183 (1989-05-01), Yamatsu et al.
patent: 4977187 (1990-12-01), Horrobin
patent: 5043268 (1991-08-01), Stock
patent: 5145611 (1992-09-01), Wolff et al.
patent: 5158975 (1992-10-01), Guichardant et al.
Gill, M., "3-[(7Z)-hexadecenyl]-4-metholfuran-2,5-dione from Piptoporus australienisis", Phytochemistry, 21:1786-1788 (1982).
Turner, W. B., et al., "Secondary Metabolites Derived from Intermediates of the Tricarboxylic Acid Cycle", Fungal Metabolites II, Academic Press, pp. 367-383 (1983).
Biller, S. A., "The First Potent Inhibitor of Squalene Synthase: A Profound Contribution of an Ether Oxygen to Inhibitor--Enzyme Interaction", J. Am. Chem. Soc., 113, 8522-8524 (1991).
Goldstein, J. L., et al., "Nonfarnesylated Tetrapeptide Inhibitors of Protein Farnesyltransferase", The Journal of Biological Chemistry, vol. 266, No. 24, pp. 15575-15578 (1991).

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