Antihyperlipidemic and antiatherosclerotic trisubstituted urea c

Details Antihyperlipidemic and antiatherosclerotic trisubstituted urea c Antihyperlipidemic and antiatherosclerotic trisubstituted urea c

1990-02-05

1991-02-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514270, 514274, 514333, 514335, 514336, 514337, 514349, 514352, 514357, 514432, 514438, 514456, 514471, 514510, 514564, 514596, 514598, 544316, 544331, 544332, 546261, 546263, 546265, 546274, A61K 3117, A61K 3144, C07C27528, C07D21375

Patent

active

049944657

ABSTRACT:
Certain trisubstituted urea compounds as potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase, their method of manufacture, pharmaceutical compositions containing such compounds as well as methods of inhibiting the interstitial absorption of cholesterol and lowering blood plasma cholesterol with such compounds as described.

REFERENCES:
patent: 3852343 (1974-12-01), Krapcho
patent: 4387106 (1983-06-01), DeVries et al.
patent: 4397868 (1983-08-01), DeVries et al.
patent: 4623662 (1986-11-01), DeVries

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