Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-07
1993-11-09
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, A61K 31335, C07D31908
Patent
active
052603326
ABSTRACT:
New Zaragozic acids have been isolated from a culture of MF5465. These compounds and their derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
REFERENCES:
patent: 5026554 (1991-06-01), Bartizal et al.
Baxter et al, Squalestatin 1, A Potent Inhibitor of Squalene Synthase Which Lowers Serum Cholesterol in Vivo, J. Biol. Chem., vol. 267, pp. 11705-11708 (1992).
Chan Nicky
DePrima Joseph F.
Dolan Catherine A.
Merci & Co., Inc.
Winokur Melvin
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