Process and composition for increasing squalene and sterol accum

Details Process and composition for increasing squalene and sterol accum Process and composition for increasing squalene and sterol accum

1994-12-08

1996-12-31

Fox, David T.

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

The polynucleotide alters fat, fatty oil, ester-type wax, or...

800250, 435 691, 4351723, 4352404, A01H 500, C12N 1500, C12N 1582

Patent

active

055896197

ABSTRACT:
A process of increasing squalene and sterol accumulation in a transgenic plant by increasing the amount of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The amount is preferably increased by transforming plant cells with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity, and a promoter suitable for driving the expression of said polypeptide to form a transformed plant cell and regenerating a transgenic plant from that transformed cell. Also disclosed are a process of increasing pest resistance in a transgenic plant, transgenic plants and transgenic seeds capable of germinating into transgenic plants.

REFERENCES:
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5306862 (1994-04-01), Chappell et al.
patent: 5365017 (1994-11-01), Chappell et al.
Basson et al., Molecular and Cellular Biology, 8:3797-3808 (1988).
Klein et al., Plant Physiol, 91:440-444 (1989).
Fromm et al., Nature, 319:791-793 (1986).
Odell et al., Nature, 313 (1985).
Marcotte et al., Nature, 335:454-457 (1988).
Fromm et al., Proc. Natl. Acad. Sci., USA, 82:5824-5828 (1985).
Bytebier et al., Proc. Natl. Acad. Sci., 84:5345-5349 (1987).
Klein et al., Proc. Natl. Acad. Sci., 85:8502-8505 (1988).
Berger et al., Proc. Natl. Acad. Sci., 8402-8406 (1989).
Yang et al., Proc. Natl. Acad. Sci., 87:4144-4148 (1990).
Fraley et al., Proc. Natl. Acad. Sci., 80:4803-4807 (1983).
Rine et al., Proc. Natl. Acad. Sci., 80:6750-6754 (1983).
Schardi et al., Gene 61:1-11 (1987).
Liscum et al., The Journal of Biological Chemistry, 260:522-530 (1985).
Jorgensen et al., Mol. Gen. Genet, 207:471-477.
Uchimiya et al., Mol. Gen. Genet, 204:204-207 (1986).
Spielman et al., Mol. Gen. Genet, 205:34-41 (1986).
Poulsen et al., Mol. Gen. Genet, 205:193-200.
Bard et al., Journal of General Microbiology, 125:415-420 (1981).
Vasil, I. K., Bio/Technology, 8:797 (1990).
Wenzler et al., Plant Molecular Biology, 12:41-50 (1989).
Keller et al., The EMBO Journal, 8:1309-1314 (1989).
Simpson et al., Science, 233:34-38 (1986).
Brown et al., Journal of Lipid Research, 21:505-517 (1980).
Caberera et al., J. Biol. Chem., 261(8):3578-3583 (1986).
Hasumi et al., Eur. J. Biochem., 164:547-552 (1987).
Jordan-Stark et al., J. of Biol Chem., 264:17919-17923.
Orci et al., Cell, 36:835-845 (1984).
Chin et al., Proc. Natl. Acad. Sci., USA 79:1185-1189.
Goldstein et al., Nature, 343:425-430 (1990).
Luskey, K. L., Molecular and Cellular Biology, 7(5):1881.
Benfey et al., Science, 244:174 (1989).
Langridge et al., Proc. Natl. Acad. Sci., USA, 86:3219.
Mayerhofer et al., The EMBO Journal, 10(3):697 (1991).
Toriyama et al. Biotechnology, 6:1072 (1988).
Vogeli et al., Plant Physiol., 88(4):1291-1296 (1980).
Caelles et al., Plant Molecular Biology, 13:627-638 (1991).
Chappell et al., Plant Physiology, (Suppl) 96(1):127 (1991) (Abstract #853).
Narita et al., The Plant Cell, 1:181-190 (1989).
Chin et al., Mol. Cell. Biol., 5(4):634-641 (1985).
Learned et al., Proc. Natl. Acad. Sci. USA, 86:2779-2783 (1989).
LaGrimini et al., The Plant Cell, 2:7-18 (1990).
Shigematsu et al., Agr. & Biol. Ch., 46(11):2877-2879 (1982).
Vaeck et al., Nature, 328:33-37 (1987).
Bradford et al., Can. J. Bot., 60:1469-1473 (1982).
Gil et al (1985) Cell 41:249-258.
Downing et al (1980) Biochem Biophys. Res. Comm 94(3):974-979.
Horsch et al (1985) Science 227:1229-1231
Chin et al (1984) Nature 308:613-617.
Chappel et al. (1989) Plant Cell Reports 8:48-52.

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