Pyrazines, pyrimidines and pyridazines useful in the treatment o

Details Pyrazines, pyrimidines and pyridazines useful in the treatment o Pyrazines, pyrimidines and pyridazines useful in the treatment o

1991-10-10

1993-11-09

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 514216, 514252, 514253, 514254, 514256, 514269, 514272, 514274, 540582, 540598, 540601, 544238, 544298, 544300, 544310, 544315, 544316, 544317, 544318, 544319, 544320, 544322, 544324, 544328, 544331, 544333, 544405, A61K 3155, A61K 31495, A61K 3150, C07D41304, C07D45302, C07D45102, C07D20952

Patent

active

052602931

ABSTRACT:
The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms thereof with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.

REFERENCES:
Chem. Abstracts vol. 81, No. 15 (Oct. 14, 1974) Columbus, Ohio p. 469.
Journal of Med. Chem. vol. 24, No. 12, (1981) pp. 1475-1482.
Bull. Des Societes Chimiques Belges, vol. 75, No. 1-2, (1966) pp. 5-16.
Vestnik Slovenskega Kemijskega Drustva, vol. 33, No. 3, pp. 197-215.
TIPS, Feb. 1988, pp. 44-48.
TIPS, Feb. 1986, pp. 56-59.
Nature 283, (5742), pp. 90-92 (Jan. 3, 1980).

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