Method for diagnosing tumors

Details Method for diagnosing tumors Method for diagnosing tumors

1992-01-30

1993-11-09

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 63, 436 64, 436 86, C12Q 168, G01N 3348

Patent

active

052601919

ABSTRACT:
A method for determining the developmental stage of a tumor is disclosed. The method comprises the steps of isolating tumor cells, dividing the cells into two samples, transducing one sample with a reporter gene, transducing the other sample with both a reporter gene and a staging gene (wherein the staging gene corresponds to a gene that is differentially expressed in neoplastic and normal cells and is chosen by its ability to be predictive of a certain stage of neoplastic development), analyzing both samples for the level of expression of the reporter gene and comparing the expression level in the samples. In a particularly advantageous embodiment of the invention, the staging gene is JR-ras and the reporter gene is lux.

REFERENCES:
patent: 4945050 (1990-07-01), Sanford et al.
patent: 5015580 (1991-05-01), Christou et al.
Freifelder (1987), Molecular Biology, 2nd Ed., (Jones & Bartlett Publishers, Boston) p. 792.
Marx, J. "Possible New Cancer Gene Found," Science, p. 1317 (Mar. 15, 1991).
Marx (1989), Science 246:1386-1388.

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