Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-01-29
1995-11-21
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D22104
Patent
active
054688604
ABSTRACT:
Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.B-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering said product finasteride.
Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
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Dolling Ulf H.
McCauley James A.
Varsolona Richard J.
Daus Donald G.
Fitch Catherine D.
Merck & Co. , Inc.
Quagliato Carol S.
Winokur Melvin
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