Tripterinin compound and method

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514825, 549275, 549281, A61K 3135

Patent

active

054687721

ABSTRACT:
An immunosuppressive compound having the structural formula: ##STR1## is disclosed, along with immunosuppression treatment methods which employ the compound.

REFERENCES:
patent: 4005108 (1977-01-01), Kupchan et al.
Yang, S.-X., et al., "Immunosuppression of Triptolide and Its Effect on Skin Allograft Survival," Int. J. Immunopharmac. 14(6): 963-969 (1992).
Briggs, J. D., "A critical review of immunosuppressive therapy," Immunol. Let. 29:89-94 (1991).
Chen, K., et al., "Anti-AIDS Agents, 4. Tripterifordin, a Novel Anti-HIV Principle From Tripterygium wilfordii: Isolation and Structural Elucidation," J. Nat. Prod. 55(1):88-92 (1992).
Huying, S., et al., "Effects of Tripterygium wilfordii on the Menstruation of 50 Patients Suffering From Rheumatoid Arthritis--With a Summary of Its Therapeutic Effects in 12 Cases of Menorrhagia," J. Trad. Chin. Med. 4(3):237-240 (1984).
Juling, G., et al., "Tripterygium wilfordii Hook f in Rheumatoid Arthritis and Ankylosing Spondylitis," Chin. Med. J. 94(7):405-412 (1981).
Keown, P. A., "Annual Review of Transplantation," from Clinical Transplants 1991 (P. Terasaki, Ed., UCLA Tissue Typing Laboratory, Los Angelos, California), pp. 205-223.
Li, X. W., and Weir, M. R., "Radix Tripterygium Wilfordii --A Chinese Herbal Medicine With Potent Immunosuppressive Properties," Transplantation 50(1):82-86 (1990).
Meifang, C., et al., "Treatment of Chronic Nephritis with Tripterygium Hypoglaucum," J. Trad. Chin. Med. 3(3):219-222 (1983).

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