Substituted pyrroloanthracenes and -diones

Details Substituted pyrroloanthracenes and -diones Substituted pyrroloanthracenes and -diones

1993-12-09

1995-05-02

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514300, 514307, 514410, 514323, 544105, 546113, 546139, 546201, 546208, 548419, 556407, C07D26528, C07D20956, A61K 3140

Patent

active

054119600

ABSTRACT:
Substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes or N-unsubstituted pyrroloanthracenes with appropriately substituted alkylamines. The compounds can be employed as active ingredients in medicaments, in particular as immunomodulators.

REFERENCES:
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patent: 4804751 (1989-02-01), Abou-Gharbia
Blue, M. L., J. F. Daley, H. Levine, K. A. Craig and S. F. Schlossmann, 1986, "Biosynthesis and surface expression of T8 by peripheral blood T4+ cells in vitro," J. Immunol. 137, 1202.
K. M. Connolly et al., 1989, Agents and Actions 27, 328-331, Differential effects of . . . arthritic rats.
M. E. J. Billingham et al., 1989, J. Exp. Med. 171, 339-344, Amycobacterial . . . Arthritogenic.
Aune, T. M. Kelley, U.A., Rangers, and Michael P. Bombara, M. P., 1990, J. Immunol. 145, 1826-1831.
Leon Sokoloff, Int. Rev. Exp. Pathol. 26k, 107; Animal Models of Rheumatoid Arthritis (1984).

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