Methods of normalizing metabolic parameters in diabetics

Details Methods of normalizing metabolic parameters in diabetics Methods of normalizing metabolic parameters in diabetics

1993-02-16

1995-11-21

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 530324, C07K 1400, A61K 3816

Patent

active

054687276

ABSTRACT:
The invention relates to a method of diagnosing and treating individuals with diabetes or at risk to develop diabetes mellitus. In particular, gastric emptying determinations are used to assess risk. Risk or early symptoms associated with subsequent development of diabetes mellitus may be controlled or alleviated by delaying gastric emptying. Delay or inhibition of gastric emptying is sufficient to restore gastric emptying within normal ranges as determined by restoration of typical glucose metabolic parameters such as blood glucose and insulin levels to normal or near normal ranges. The method is also useful in prophylactic treatment of individuals at high risk to develop diabetes mellitus, such as the obese, those with a family history of diabetes and those of particular ethnic and minority groups.

REFERENCES:
Koizuma et al., Biomed. Res. (1989) 10 (Suppl. 1) pp. 45-50. Abstract.
Hill et al., Physiol. Behav. (1990 Aug). 48(2) pp. 241-246. Abstract.
Barnett et al., Gastroenterology 94(3) 739-44 (1988).
Granneman et al., Am. J. Physiol. 247 (6 pt. 2) R1054-R1061 (1984).

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