Hepatoma treatment with somatostatin analogs

Details Hepatoma treatment with somatostatin analogs Hepatoma treatment with somatostatin analogs

1992-02-25

1995-05-02

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 11, 514 14, 514 15, 514 17, A61K 706

Patent

active

054119430

ABSTRACT:
A method for treating liver cancer in a mammalian subject. The method includes administering to the subject a composition which contains a therapeutically effective amount of an octapeptide of the following formula: ##STR1## wherein, A.sub.1 is D-.beta.-Nal or D-Phe; A.sub.2 is Phe, pentafluro-Phe, or p-substituted X-Phe where X is a halogen, NH.sub.2, NO.sub.2, OH, or C.sub.1-3 alkyl; A.sub.3 is Thr, Ser, Phe, Val, .varies.-aminobutyric acid, or Ile; A.sub.4 is Thr, .beta.-Nal, or Trp; and Y is NH.sub.2 or OH; or a pharmaceutically acceptable salt or complex thereof.

REFERENCES:
patent: 5073541 (1991-12-01), Taylor et al.
Chou et al., The American Society for Clinical Investigation, Inc. 79:175, 1987.

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