Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1993-12-07
1995-11-21
Spiegel, Carol A.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
422 58, 422 60, 435 71, 435 792, 435 793, 435 794, 435 795, 435970, 435973, 435974, 436514, 436530, 436525, 436538, 436540, 436807, 436810, G01N 33543
Patent
active
054686482
ABSTRACT:
The present invention provides chromatographic assay devices that can perform multiple assays simultaneously in the same test strip, as well as methods for their use. One of the assays can be an immunological assay to detect an antigen, such as human chorionic gonadotropin, while another assay can be a serological assay to detect an antibody, such as anti-rubella antibody. An assay device according to the present invention can comprise: (1) a first opposable component including at least one chromatographic medium having a specific binding partner to the first analyte and a specific binding partner to the second analyte immobilized thereto in separate, discrete, non-overlapping zones; and (2) a second opposable component including an absorber. The first and second opposable components are configured such that bringing the first and second opposable components into opposition causes the absorber to come into operable contact with at least one chromatographic medium so that the zone containing the specific binding partner to the first analyte is functionally divided from the zone containing the specific binding partner to the second analyte so that both analytes can be detected.
REFERENCES:
patent: 3723064 (1973-03-01), Liotta
patent: 3798004 (1974-03-01), Zerachia et al.
patent: 3888629 (1975-06-01), Bagshawe
patent: 3915647 (1975-10-01), Wright
patent: 3933594 (1976-01-01), Mulligan
patent: 3966897 (1976-06-01), Renn et al.
patent: 3985867 (1976-10-01), Redshaw
patent: 3990850 (1976-11-01), Friedman et al.
patent: 3993451 (1976-11-01), Verbeck
patent: 3996006 (1976-12-01), Pagano
patent: 4018662 (1977-04-01), Ruhenstroth-Bauer et al.
patent: 4094647 (1978-06-01), Deutsch et al.
patent: 4108729 (1978-08-01), Mennen
patent: 4110079 (1978-08-01), Schaeffer
patent: 4168146 (1979-09-01), Grubb et al.
patent: 4189304 (1980-02-01), Adams, Jr. et al.
patent: 4223089 (1980-09-01), Rothe et al.
patent: 4246339 (1981-01-01), Cole et al.
patent: 4299916 (1981-11-01), Litman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4333733 (1982-06-01), Sanford et al.
patent: 4365970 (1982-12-01), Lawrence et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4427769 (1984-01-01), Adlecreutz et al.
patent: 4435504 (1984-03-01), Zuk et al.
patent: 4442204 (1984-04-01), Greenquist et al.
patent: 4444193 (1984-04-01), Fogt et al.
patent: 4446232 (1984-05-01), Liotta
patent: 4447526 (1984-05-01), Rupchock et al.
patent: 4447529 (1984-05-01), Greenquist et al.
patent: 4459358 (1984-07-01), Berke
patent: 4461829 (1984-07-01), Greenquist
patent: 4474878 (1984-10-01), Halbert et al.
patent: 4477575 (1984-10-01), Vogel et al.
patent: 4517288 (1985-05-01), Giegel et al.
patent: 4533629 (1985-08-01), Litman et al.
patent: 4582811 (1986-04-01), Pucci et al.
patent: 4594327 (1986-06-01), Zuk
patent: 4623461 (1986-11-01), Hossom et al.
patent: 4629690 (1986-12-01), Weng et al.
patent: 4642285 (1987-02-01), Halbert et al.
patent: 4668619 (1987-05-01), Greenquist et al.
patent: 4678757 (1987-07-01), Rapkin et al.
patent: 4683197 (1987-07-01), Gallati
patent: 4690907 (1987-09-01), Hibino et al.
patent: 4693834 (1987-09-01), Hossom
patent: 4703017 (1987-10-01), Campbell et al.
patent: 4717656 (1988-01-01), Swanljung
patent: 4738823 (1988-04-01), Engelmann
patent: 4740468 (1988-04-01), Weng et al.
patent: 4752562 (1988-06-01), Sheiman et al.
patent: 4761381 (1988-08-01), Blatt et al.
patent: 4775636 (1988-10-01), Moeremans et al.
patent: 4780280 (1988-10-01), Berger et al.
patent: 4786594 (1988-11-01), Khanna et al.
patent: 4789526 (1988-12-01), Matkovich
patent: 4789629 (1988-12-01), Baker et al.
patent: 4790979 (1988-12-01), Terminiello et al.
patent: 4797260 (1989-01-01), Parker
patent: 4803170 (1989-02-01), Stanton et al.
patent: 4806311 (1989-02-01), Greenquist
patent: 4806312 (1989-02-01), Greenquist
patent: 4810470 (1989-03-01), Burkhardt et al.
patent: 4814142 (1989-03-01), Gleisner
patent: 4816224 (1989-03-01), Vogel et al.
patent: 4818677 (1989-04-01), Hay-Kaufman et al.
patent: 4826759 (1989-05-01), Guire et al.
patent: 4837373 (1989-06-01), Gunkel et al.
patent: 4837395 (1989-06-01), Leeder et al.
patent: 4843000 (1989-06-01), Litman et al.
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4855240 (1989-08-01), Rosenstein et al.
patent: 4857453 (1989-08-01), Ullman et al.
patent: 4859612 (1989-08-01), Cole et al.
patent: 4861711 (1989-08-01), Friesen et al.
patent: 4868108 (1989-09-01), Bahar et al.
patent: 4876067 (1989-10-01), Deneke et al.
patent: 4877586 (1989-10-01), Devaney, Jr. et al.
patent: 4879215 (1989-11-01), Weng et al.
patent: 4883764 (1989-11-01), Kloepfer
patent: 4900663 (1990-02-01), Wie et al.
patent: 4912034 (1990-03-01), Kalra et al.
patent: 4916056 (1990-04-01), Brown, III et al.
patent: 4916078 (1990-04-01), Klose et al.
patent: 4918025 (1990-04-01), Grenner
patent: 4920046 (1990-04-01), McFarland et al.
patent: 4938927 (1990-07-01), Kelton et al.
patent: 4939098 (1990-07-01), Suzuki et al.
patent: 4943522 (1990-07-01), Eisinger et al.
patent: 4952517 (1990-08-01), Bahar
patent: 4956275 (1990-09-01), Zuk et al.
patent: 4956302 (1990-09-01), Gordon et al.
patent: 4959307 (1990-09-01), Olson
patent: 4960691 (1990-10-01), Gordon et al.
patent: 4963325 (1990-10-01), Lennon et al.
patent: 4963468 (1990-10-01), Olson
patent: 4977078 (1990-12-01), Niimura et al.
patent: 4981786 (1991-01-01), Dafforn et al.
patent: 4999285 (1991-03-01), Stiso
patent: 4999287 (1991-03-01), Allen et al.
patent: 5006464 (1991-04-01), Chu et al.
patent: 5006474 (1991-04-01), Horstman et al.
patent: 5017009 (1991-05-01), Schutt et al.
patent: 5030555 (1991-07-01), Clemmons
patent: 5030558 (1991-07-01), Litman et al.
patent: 5039607 (1991-08-01), Skold et al.
patent: 5051237 (1991-09-01), Grenner et al.
patent: 5071746 (1991-12-01), Wilk et al.
patent: 5073484 (1991-12-01), Swanson et al.
patent: 5075078 (1991-12-01), Osikowicz et al.
patent: 5079142 (1992-01-01), Coleman et al.
patent: 5079174 (1992-01-01), Buck et al.
patent: 5085987 (1992-02-01), Olson
patent: 5085988 (1992-02-01), Olson
patent: 5096809 (1992-03-01), Chen et al.
patent: 5100619 (1992-03-01), Baker et al.
patent: 5104811 (1992-04-01), Berger et al.
patent: 5104812 (1992-04-01), Kurn et al.
patent: 5106582 (1992-04-01), Baker
patent: 5106758 (1992-04-01), Adler et al.
patent: 5110550 (1992-05-01), Schlipfenbacher et al.
patent: 5114673 (1992-05-01), Berger et al.
patent: 5114862 (1992-05-01), Brenneman
patent: 5120643 (1992-06-01), Ching et al.
patent: 5120662 (1992-06-01), Chan et al.
patent: 5132208 (1992-07-01), Freitag et al.
patent: 5135872 (1992-08-01), Pouletty et al.
patent: 5135873 (1992-08-01), Patel et al.
patent: 5137804 (1992-08-01), Greene et al.
patent: 5137808 (1992-08-01), Ullman et al.
patent: 5141850 (1992-08-01), Cole et al.
patent: 5156952 (1992-10-01), Litman et al.
patent: 5158869 (1992-10-01), Pouletty et al.
patent: 5160486 (1992-11-01), Schlipfenbacher et al.
patent: 5162237 (1992-11-01), Messenger et al.
patent: 5164294 (1992-11-01), Skold et al.
patent: 5177021 (1993-01-01), Kondo
patent: 5182191 (1993-01-01), Fan et al.
patent: 5185127 (1993-02-01), Vonk
patent: 5188939 (1993-02-01), Mangold et al.
patent: 5188966 (1993-02-01), Eikmeier et al.
patent: 5202267 (1993-04-01), Ditlow et al.
patent: 5202268 (1993-04-01), Kuhn et al.
patent: 5209904 (1993-05-01), Forney et al.
patent: 5223436 (1993-06-01), Freitag et al.
patent: 5234813 (1993-08-01), McGeehan et al.
patent: 5248619 (1993-09-01), Skold et al.
patent: 5256372 (1993-10-01), Brooks et al.
patent: 5258163 (1993-11-01), Krause et al.
patent: 5260193 (1993-11-01), Olson
patent: 5260222 (1993-11-01), Patel et al.
patent: 5264180 (1993-11-01), Allen et al.
patent: 5275785 (1994-01-01), May et al.
patent: 5278079 (1994-01-01), Gubinski et al.
patent: 5308580 (1994-05-01), Clark
patent: 5314804 (1994-05-01), Boguslaski et al.
T. C. J. Gribnau et al., "Particle-Labelled Immunoassays: A Review," J. Chromatograph. 376:175-189 (1986)
SmithKline Diagnostics, Inc.
Spiegel Carol A.
LandOfFree
Interrupted-flow assay device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Interrupted-flow assay device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interrupted-flow assay device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1136380