Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-02-25
1995-05-02
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435967, 436526, 436815, 5303898, 5303913, 530404, 530405, 530807, G01N 33553
Patent
active
054118697
ABSTRACT:
There is provided a standard for use in testing for captan in immunoassays. This standard has the structure THPD--(CH.sub.2).sub.x --(R.sup.3).sub.y --R.sup.1 wherein THPD is cis-1,2,3,6-tetrahydrophthalimido, x is an integer from 1 to 10, R.sup.1 selected from the group consisting of --COOH, --NH.sub.2, --NO.sub.2, --SH and --OH, R.sup.3 is an aryl moiety and y is 0 or 1. Compounds of this general structure are known, they mimic the immunological reaction of captan and related compounds which are not stable in water and thus cannot be satisfactorily used as standards in testing for the presence and level of presence of captan and related compounds. There is also provided a method of carrying out such testing, utilizing such standards in which the standard (I) is coupled to a protein that is large enough to elicit an immune response in warm blooded animals, to yield compound (II). THPD--(CH.sub.2).sub.x --(R.sup.3).sub.y --R.sup.2 --[--C*--]--[LP] (II), wherein C** is a coupling agent capable of coupling a member of the group R.sup.1 to a protein, R.sup.2 is the residue remaining when R.sup.1 is coupled with coupling agent C**, C* is the residue remaining from coupling agent C** after coupling a member of the group R.sup.1 to a protein and LP is a protein of sufficient size to generate an antibody response in a warm blooded animal.
REFERENCES:
patent: 5147786 (1992-09-01), Feng et al.
"Captan", publication of the Ohmicron Corp., Feb. 27, 1992.
J. Gosling, Clin. Chem., vol. 36, No. 8, 1408-1427 (1990) "A decade of development in Immunoassay Methodology".
N. Wolfe et al., J. Agric Food Chem., vol. 24, No. 5, 1041-1045 (1976), "Captan Hydrolysis".
W. Newsome et al., 203rd ACS Nat'l Meeting, San Francisco, Calif., Apr. 5-10, 1992, Abstr Pap Am Chem Soc 203 (1-3) 1992.
Fleeker James R.
Herzog David P.
Itak Jeanne A.
Behr Omri M.
Ceperley Mary E.
McDonald Matthew J.
Ohmicron Corporation
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