Process for the preparation of substituted indazoles

Details Process for the preparation of substituted indazoles Process for the preparation of substituted indazoles

1976-06-01

1978-06-20

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23156

Patent

active

040963330

ABSTRACT:
Substituted indazoles that have the structural formula ##STR1## wherein X represents halogen, trihalomethyl, nitro, --SO.sub.2 R, cyano, acoyl, acoylamino, aroylamino, or --COOR'; R represents hydroxyl, halogen, alkyl, haloalkyl, alkylamino, phenyl, or substituted phenyl; R' represents hydrogen, halogen, alkyl, haloalkyl, phenyl, or substituted phenyl; and n represents a number in the range of 1 to 4 are prepared by the direct nitrosation of the corresponding 2-methylacetanilide with an alkali metal nitrite or alkaline earth metal nitrite under conditions of controlled acidity in the presence of a dehydrating agent at a temperature in the range of 50.degree.-120.degree. C.

REFERENCES:
patent: 3862958 (1975-01-01), Ruechardt et al.
patent: 3988347 (1976-10-01), DiBella
Morrison et al., Organic Chemistry p. 557.
House, Modern Synthetic Organic Reactions, p. 429.

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