Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Hemic or immune system
Patent
1992-12-23
1995-05-02
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Hemic or immune system
424 9, 4241841, 800 2, 800DIG5, 53038815, A61K 3500, A61K 3900, A61K 4900
Patent
active
054117496
ABSTRACT:
Human lymphoid tissue is introduced into an immunocompromised host to provide opportunities to investigate the effect of stimuli on the human immune system and obtain information and products from the stimulus. Particularly, methodology is provided for the production of human monoclonal antibodies by introducing lymphoid tissue into an immunocompromised host, stimulating the B-lymphocytes with an appropriate immunogen, harvesting the tissue and immortalizing and/or cloning the B-lymphocytes under conditions to obtain a stable supply of monoclonal antibodies.
REFERENCES:
McCune et al., Science 241: 1632-1639 (1988).
Povlsen et al., Nature 248: 247-249 (1974).
Bosma et al., Nature 301: 527-530 (1983).
Kozbor et al., Immunology Today 4(3): 72-79 (1983).
Mosier et al., Nature 335: 256-259 (1988).
Morrison et al., Amer. N.Y. Acad. Sci. 507: 187-198 (1988).
Huse et al., Science 246: 1275-1281 (1989).
Kaneshima Hideto
Mayo Susan K.
McCune Joseph M.
Namikawa Reiko
Chambers Jasemine C.
Rowland Bertram I.
Sherwood Pamela J.
Systemix, Inc.
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