Process for the preparation of p. isobutyl-hydratropic

Details Process for the preparation of p. isobutyl-hydratropic Process for the preparation of p. isobutyl-hydratropic

1976-11-30

1978-06-20

Myers, Jane S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560176, C07C 6304

Patent

active

040961770

ABSTRACT:
A process for the synthesis of Ibuprofen, p - isobutyl hydrotropic acid is described based upon the aromatization reaction which takes place when a dialkyl .alpha.-acetyl-.alpha.-[(5-methyl-3-oxo)-hexyl]-.alpha.'-methyl-succinate (II) is heated at temperatures of about 200.degree. with a strong acid, or a salt of a strong acid with an organic base.

REFERENCES:
patent: 3852286 (1974-12-01), Hall et al.
patent: 4008270 (1977-02-01), White

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