Dehydroxylation of aminosugars

Details Dehydroxylation of aminosugars Dehydroxylation of aminosugars

1973-12-20

1977-06-14

Gotts, Lewis

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 4, 536 10, 536 12, 536 14, C07H 1700

Patent

active

040298833

ABSTRACT:
Dehydroxylation of aminoglycoside antibiotics is carried out by halogenation of phosphorylated aminoglycoside antibiotics followed by reduction of thus halogenated antibiotics. The dehydroxylation process is entirely new and gives the final product in a high yield. The resulting deoxyaminoglycoside antibiotics are effective against microorganisms including aminoglycoside antiobiotics-resistant microorganisms.

REFERENCES:
patent: 3721664 (1973-03-01), Hopper
patent: 3753973 (1973-08-01), Umezawa et al.
Umezawa et al., Science 157, pp. 1559-1561, (1967).
Umezawa et al., J. of Antibiotics, vol. 24, No. 4, pp. 274-275, (1971).
Chemical Abstracts, vol. 79, p. 347, (76912a), (1973).
Houben and Wehyl, "Methoden der Organischen Chemie," 1964, pp. 187 & 255.
Wagner & Zook, Synthetic Organic Chemistry, 1953 Wiley and Sons Inc., New York, p. 8.

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