Dihydroxynaphthalene derivatives

Details Dihydroxynaphthalene derivatives Dihydroxynaphthalene derivatives

1989-10-20

1990-06-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 56, 562462, 562466, C07C 6976

Patent

active

049373714

ABSTRACT:
There are described dihydroxy naphthalene derivatives of the formula ##STR1## in which R.sub.1 is hydrogen, lower alkyl or benzyl, R.sub.2 is hydrogen, hydroxy or lower alkanoyloxy, R.sub.3 is hydrogen or lower alkyl, R.sub.4 is hydrogen or halogen, R.sub.5 is hydrogen, acyl, methyl or benzyl, m is 0 or 1, and n is an integer from 2 to 10, as well as salts thereof with pharmaceutically acceptable bases when R.sub.1 is hydrogen.
These compounds are useful as agents for the treatment of inflammatory bowel diseases, for instance, colitis, as pro-drugs, or as intermediates for the preparation of such compounds.

REFERENCES:
patent: 4351950 (1982-09-01), Sircar
patent: 4374262 (1983-02-01), McGinnis
patent: 4391731 (1983-07-01), Bollen et al.

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