Synthesis of thiophene-containing prostaglandin endoperoxide app

Details Synthesis of thiophene-containing prostaglandin endoperoxide app Synthesis of thiophene-containing prostaglandin endoperoxide app

1984-06-04

1986-01-07

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 22, 549 32, 549 60, 549 76, 549 77, 549 78, 544235, 546141, 546153, 514444, 514438, C07D33324, A61K 3138

Patent

active

045635374

ABSTRACT:
New organopalladium reactions involving the addition of thienylpalladium compounds to strained bicyclic alkenes, and subsequent chain extension reactions employing the chemistry of organopalladium compounds are disclosed. By these techniques a large number of bicyclic prostaglandin analogs are prepared, which are useful as inhibitors of arachidonic acid induced blood platelet aggregation, and are specific inhibitors of thromboxane synthetase.

REFERENCES:
patent: 4351949 (1982-09-01), Larock
patent: 4520207 (1985-05-01), Larock

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