Substituted triazoles as angiotensin II inhibitors

Details Substituted triazoles as angiotensin II inhibitors Substituted triazoles as angiotensin II inhibitors

1993-06-07

1994-09-13

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5482644, C07D24912

Patent

active

053470117

ABSTRACT:
This invention relates to novel bis-biphenyl substituted 3-mercapto-1,2,4-tetrazoles and to pharmaceutically acceptable salts thereof.
The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy.
The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.

REFERENCES:
patent: 5093346 (1992-03-01), Corini et al.

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