.alpha.-Alkoxyimino-.beta.-oxo-.gamma.-Bromobutyric acid

Details .alpha.-Alkoxyimino-.beta.-oxo-.gamma.-Bromobutyric acid .alpha.-Alkoxyimino-.beta.-oxo-.gamma.-Bromobutyric acid

1978-01-18

1980-05-27

Evans, Joseph E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562560, 560142, 560145, C07C11912

Patent

active

042051800

ABSTRACT:
Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into methoxy group, R.sup.4 represents hydrogen or a residue of a nucleophilic compound and R.sup.8 represents hydrogen or a halogen, or a pharmaceutically acceptable salt or ester thereof, have strong antibiotic properties against a wide variety of microorganisms including gram-positive bacteria as well as gram-negative ones, especially by oral administration and can be used as therapeutic agent for various bacterial infections of animals including human beings.

REFERENCES:
patent: 2470083 (1949-05-01), Hartung
patent: 2542812 (1950-02-01), Hartung
patent: 3038007 (1962-06-01), Reeve
patent: 3104258 (1963-09-01), Ferris
patent: 3661977 (1972-05-01), Uchimoto
patent: 4029781 (1977-06-01), Berger
patent: 4068075 (1978-01-01), Menard
Hatanaka, J. Med. Chem., vol. 16, pp. 978-984 (1973).

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