Glaucoma treatment

Details Glaucoma treatment Glaucoma treatment

1991-04-23

1994-09-13

Fay, Zohreh A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514171, 5142362, 514400, 514423, 514538, 514540, 514542, 514601, 514605, 514617, 514625, 514913, A61K 3700, A61K 3156, A61K 31535, A61K 31415

Patent

active

053468872

ABSTRACT:
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, (alpha, alpha) -dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkylamino.

REFERENCES:
patent: 4442089 (1984-04-01), Horowitz et al.
patent: 4569937 (1986-02-01), Baker et al.
patent: 4587258 (1986-05-01), Gold et al.
patent: 4845079 (1989-07-01), Luly et al.

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