Imidobisphosphoric acids, and use thereof

Details Imidobisphosphoric acids, and use thereof Imidobisphosphoric acids, and use thereof

1997-12-12

1999-08-10

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 63, 556405, 558157, 562 10, A61K 3166, C07F 924, C07F 922

Patent

active

059359471

ABSTRACT:
There are described compounds of the formula I ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.10)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.6 -C.sub.10)-aryl or Het, each of which can be substituted by halogen, --OH, --NH.sub.2, --NH--CO--R.sup.7, --O--CO--R.sup.7 and --N--(R.sup.8).sub.2 where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl and R.sup.8, independently of one another, is hydrogen or (C.sub.1 -C.sub.2)-alkyl or in which R.sup.1 is the radical of the formula II ##STR2## in which n is an integer from 3 to 10, m is zero to 3, R.sup.6, independently of one another, is (C.sub.1 -C.sub.6)-alkyl which is optionally substituted by halogen or --NH--CO--R.sup.7, where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl, and X is absent or is (C.sub.1 -C.sub.10)-alkyl, and R.sup.2, R.sup.3, R.sup.4 or R.sup.5, independently of one another, are hydrogen, (C.sub.1 -C.sub.5) -alkyl, lithium, sodium, potassium or Si(R), where R=(C.sub.1 -C.sub.5)-alkyl, and their physiologically tolerable salts, a process for preparation of these compounds of the formula I and their use as pharmaceuticals in the prophylaxis and treatment of osteoporosis and hypercalcemia.

REFERENCES:
patent: 2798086 (1957-07-01), Coover et al.
Ding et al., "Organophosphorus Compounds. XXI. Regioselective Phosphorylation of Ambident Anions," Chemical Abstract, 108(19):663, Abstract No. 167599.
Pinchuk et al., "Reactions of N,N-Dichloro Amines with Phosphites and Phosphorochloridites," translated from Zhurnal Obschei Khimii, 45(11):2394-2396 (1975).
Naumann et al., "Synthese von Neuen Imidobisphosphorsauren," Phosphorus, Sulfur, and Silicon, 91:169-177 (1994).
Ding et al., "Regioselective Phosphorylation of Ambident Anions, Studies of Organophosphorus Compounds," Acta Chimica Sinica, 45:785-790 (1987).
English Translation of Ding et al article entitled "Regioselective Phosphorylation of Ambident Anions, Studies of Organophosphorus Compounds," as translated by the Ralph McElroy Co.
Yuan et al. "Studies on Organophosphorus Compounds, IX. C-Phosphorylation of Compounds With An Active Methylene Group," Chemical Abstracts vol. 100, No. 1, Chemical Abstract No. 100:6640p (Jan. 2, 1984).
Ding et al., "Alkylation of Para-Substituted Phenyl Allyl Ethers," Chemical Abstracts vol. 104, No. 17, Chemical Abstract No. 104:148413y, (Apr. 28, 1986).
Yuan et al., "Organophosphorus Compounds, XVIII. Synthesis and Reaction of .alpha.-Sulfonyl Phosphonates," Chemical Abstracts vol. 107, No. 25, Chemical Abstract No. 107:236852h, (Dec. 21, 1987).
Yuan et al., "Organophosphorus Compounds, XXII. Methylenebis(dialkyl Phosphonates)And Their Derivatives," Chemical Abstracts vol. 110, No. 11, Chemical Abstract No. 110:95356x, (Mar. 13, 1989).

Affiliated with

Also associated with

Rating

Imidobisphosphoric acids, and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidobisphosphoric acids, and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidobisphosphoric acids, and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1120322