Mutation assays involving blood cells that metabolize toxic subs

Details Mutation assays involving blood cells that metabolize toxic subs Mutation assays involving blood cells that metabolize toxic subs

1992-01-06

1999-08-10

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435372, 435375, C12N 1500, C12N 508

Patent

active

059358297

ABSTRACT:
The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

REFERENCES:
patent: 4302535 (1981-11-01), Skopek et al.
patent: 4532204 (1985-07-01), Crespi et al.
Freedman, H.J. et al., Cancer Res. 39:4605-4611 (1979).
Freedman, H.J. et al., Cancer Res. 39:4612-4619 (1979).
Tong, C. and Williams, G.M., Mutagen Res. 58:339-352 (1978).
Tong, C. and Williams, G.M., Mutation Res. 74:1-9 (1980).
Crespi, C. "Xenobiotic Metabolism and Mutation in Diploid Human Lymphoblasts" Ph.D. thesis received by the Library of Massachusetts Institute of Technology on Jul. 30, 1982.
Tong et al., Mutation Res. 130:53 (1984).
Gurtoo, H.L. et al., Cancer Res. 35:1235-1243 (1975).

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