Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1982-09-02
1986-01-07
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 70, 435 71, 4351723, 435 91, 435 23, 435 24, 435253, 435317, 514 2, 260112R, 935 65, C12P 2100, C12P 2102, C12P 2104, C12P 1934, C12N 1500, C12N 120, C12N 100, C12Q 138, C12Q 136, A61K 3700, C07G 700
Patent
active
045634238
ABSTRACT:
Polypeptides displaying the antigenicity of hepatitis B virus e antigens, DNA sequences coding for those polypeptides, antibodies to those polypeptides and methods of producing and using those polypeptides, antibodies and DNA sequences. The polypeptides and antibodies of this invention are characterized by their use in compositions and methods for detecting hepatitis B virus infective carriers and in evaluating the course of HBV-related active liver disease.
REFERENCES:
patent: 4021540 (1977-05-01), Pollack et al.
patent: 4102996 (1978-07-01), McAleer et al.
patent: 4118479 (1978-10-01), Prince et al.
patent: 4138287 (1979-02-01), Andersson et al.
patent: 4162192 (1979-07-01), Mizuno et al.
patent: 4164565 (1979-08-01), Prince et al.
patent: 4164566 (1979-11-01), Provost et al.
patent: 4197361 (1980-04-01), Hoff et al.
patent: 4204989 (1980-05-01), McAleer et al.
Takahashi et al.: J. Immunol. 122, 275, (1979).
P. MacKay et al., "The Conversion of Hepatitis B Core Antigen Synthesized in E. coli into e Antigen", J. Med. Virol., 8, pp. 237-243, (1981).
K. Takahashi et al., "Hepatitis B e Antigen Polypeptides Isolated from Sera of Individuals Infected with Hepatitis B Virus: Comparison with HBeAg Polypeptide Derived from Dane Particles", J. Gen. Virol., 50, pp. 49-57, (1980), [Chem. Abstracts 94: 63509j, (1981)].
H. Boyer and D. Roulland-Dussoix, "A Complementation Analysis of the Restriction and Modification of DNA in Escherichia coli", J. Mol. Biol., 41, pp. 459-472, (1969).
S. Broome and W. Gilbert, "Immunological Screening Method to Detect Specific Translation Products", Proc. Natl. Acad. Sci. USA, 75, pp. 2746-2749, (Jun. 1978).
A. Budkowska et al., "Identification of Two HBeAg Subspecificities Revealed by Chemical Treatment and Enzymatic Digestion of Liver-Derived HBcAg", J. Immunol., 123, pp. 1415-1416, (1979).
C. J. Burrell et al., "Expression in Escherichia coli of Hepatitis B Virus DNA Sequences Cloned in Plasmid pBR322", Nature, 279, pp. 43-47, (May 1979).
P. Charnay et al., "Cloning in Escherichia coli and Physical Structure of Hepatitis B Virion DNA", Proc. Natl. Acad. Sci. USA, 76, pp. 2222-2226, (1979).
D. Clewell, "Nature of Col E.sub.1 Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol", J. Bacteriol., 110, pp. 667-676, (1972).
B. J. Cohen, & Y. E. Cossart, "Application of a Screening Test for Antibody to Hepatitis B Core Antigen", J. Clin. Path., 30, pp. 709-713, (1977).
D. S. Dane et al., "Virus-Like Particles in Serum of Patients with Australian-Antigen-Associated Hepatitis", The Lancet, pp. 695-698, (Apr. 4, 1970).
J. Edman et al., "Synthesis of Hepatitis B Surface and Core Antigens in E. coli", Nature, 291, pp. 503-506, (1981).
H. A. Fields et al., "Purification and Partial Characterization of Hepatitis e Antigen", Infection & Immunity, 20, pp. 792-803, (1978).
A. Fritsch et al., "Cloning of the Genome of Hepatitis B Virus in Escherichia coli", C. R. Acad. Sc. Paris, t., 287, Ser. D, pp. 1453-1456, (Dec. 18, 1978)-translation included.
F. Galibert et al., "Nucleotide Sequence of the Hepatitis B Virus Genome (Subtype ayw) Cloned in E. coli", Nature, 281, pp. 646-650, (Oct. 25, 1979).
P. M. Kaplan et al., "DNA Polymerase Associated with Human Hepatitis B Antigen", J. Virology, 12, pp. 995-1005, (Nov. 1973).
T. A. Landers et al., "Structure of Hepatitis B Dane Particle DNA and Nature of the Endogenous DNA Polymerase Reaction", J. Virology, 23, pp. 368-376, (Aug. 1977).
L. I. Lutwick & W. S. Robinson, "DNA Synthesized in the Hepatitis B Dane Particle DNA Polymerase Reaction", J. Virology, 21, pp. 96-104, (Jan. 1977).
L. Magnius et al., "A New Antigen-Antibody System", J. Amer. Med. Assoc., 231, pp. 356-359, (1975).
L. Magnius & J. Espmark, "New Specificities in Australia Antigen Positive Sera Distinct from the LeBouvier Determinants", J. Immunol., 109, pp. 1017-1021, (1972).
M. Mandel & A. Higa, "Calcium-Dependent Bacteriophage DNA Infection", J. Mol. Biol., 53, pp. 159-162, (1970).
A. M. Maxam & W. Gilbert, "Sequencing End-Labeled DNA with Base-Specific Chemical Cleavages", Methods Enzymol., 65, pp. 499-560, (1980).
J. L. Melnick et al., "Approaching the Control of Viral Hepatitis Type B", J. Infectious Diseases, 133, pp. 210-225, (1976).
A. R. Neurath & N. Strick, "Host Specificity of a Serum Marker for Hepatitis B: Evidence that `e Antigen` has the Properties of an Immunoglobulin", Proc. Natl. Acad. Sci. USA, 74, pp. 1702-1706, (1977).
A. R. Neurath et al., J. Gen. Virol., 30, pp. 277-285, (1976).
H. Ohori et al., "Antigenic Conversion from HBcAg to HBeAg by Degradation of Hepatitis B Core Particles", Intervirology, 13, pp. 74-82, (1980).
M. Pasek et al., "Hepatitis B Virus Genes and Their Expression in E. Coli", Nature, 282, pp. 575-579, (Dec. 6, 1979).
W. S. Robinson, "The Genome of Hepatitis B Virus", Ann. Rev. Microbiol., 31, pp. 357-377, (1977).
J. J. Sninsky et al., "Cloning and Endonuclease Mapping of the Hepatitis B Viral Genome", Nature, 279, pp. 346-348, (May 24, 1979).
J. Summers et al., "Genome of Hepatitis B Virus: Restriction Enzyme Cleavage and Structure of DNA Extracted from Dane Particles", Proc. Natl. Acad. Sci. USA., 72, pp. 4597-4601, (Nov. 1975).
K. Takahashi et al., "Association of Dane Particles with e Antigen in the Serum of Asymptomatic Carriers of Hepatitis B Surface Antigen", J. Immunol., 117, pp. 102-105, (1976).
P. Valenzuela et al., "Nucleotide Sequence of the Gene Coding for the Major Protein of Hepatitis B Virus Surface Antigen", Nature, 280, pp. 814-819, (Aug. 30, 1979).
G. N. Vyas et al., "Hepatitis B Virus `e` Antigen: An Apparent Association with Lactate Dehydrogenase Isoenzyme-5", Science, 198, pp. 1068-1070, (1977).
B. G. Werner et al., "Association of e Antigen with Dane Particle DNA in Sera from Asymptomatic Carriers of Hepatitis B Surface Antigen", Proc. Natl. Acad. Sci. USA, 74, pp. 2149-2151, (May 1977).
H. Yoshizawa et al., "Demonstration of Hepatitis B e Antigen in Hepatitis B Core Particles Obtained from the Nucleus of Hepatocytes Infected with Hepatitis B Virus," J. Gen. Virol., 42, pp. 513-519, (1979).
MacKay Patricia
Murray Kenneth
Biogen N.V.
Haley, Jr. James F.
Martinell James
Pierri Margaret A.
Tanenholtz Alvin E.
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