Radioiodinated phospholipid ether analogues

Details Radioiodinated phospholipid ether analogues Radioiodinated phospholipid ether analogues

1994-09-12

1998-08-18

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 165, 424 185, A61K 5100, A61M 3614

Patent

active

057955611

ABSTRACT:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n=1-15 ##STR2## M=0-15; Z=.sup.123 I, .sup.125 I, and .sup.131 I; Y=NH.sub.2, NR.sub.2, and NR.sub.3, and R=alkyl, aralkyl.

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Andreesen et al., Cancer Research, vol. 38, pp. 3894-3899, Nov., 1978.
March et al., Advanced Organic Chemistry, p. 1100, 1985.

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