Substituted benzoxazole, benzthiazole, and benzimidazole derivat

Details Substituted benzoxazole, benzthiazole, and benzimidazole derivat Substituted benzoxazole, benzthiazole, and benzimidazole derivat

1992-06-25

1995-02-07

Henley, III, Raymond J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514313, 546153, 546154, 546155, 546156, A61K 31475, C07D21542, C07D215233

Patent

active

053875923

ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them for treating conditions as hypertension and congestive heart failure.

REFERENCES:
patent: 4920131 (1990-04-01), Huang et al.
patent: 5028615 (1991-06-01), Huang et al.
patent: 5126344 (1992-06-01), Roberts et al.
patent: 5130318 (1992-07-01), Roberts et al.
G. R. Proctor, et al., "Azabenzocycloheptenones. Part XIV. Cyclisation of Amino-acid Derivatives to Tetrahydro-1-benzazepin-5-ones and Tetrahydroquiolin-4-ones" J. Chem. Soc., Perkin Trans. I (1972), 1803-8.
R. D. Youssefyeh, et al. (principal author Huang) J. Med. Chem. (1990), 33, 1186-1194; Chem. Abstr. (1990), 112, 17, abstract 131,890u.
F-C. Huang J. Med. Chem. (1990), 33, 1194-1200.

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