Method of treating ocular inflammation

Details Method of treating ocular inflammation Method of treating ocular inflammation

1992-11-17

1995-02-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

053875893

ABSTRACT:
Disclosed is a method of treating ocular inflammation in a mammal in need of such treatment, including administering to the mammal an anti-inflammatory amount of rapamycin.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4650803 (1987-03-01), Stella et al.
patent: 4885171 (1989-12-01), Surendra et al.
patent: 5066493 (1991-11-01), Sehgal et al.
Morris et al., Med. Sci. Res. 17:877-878 (1989).
Martel et al., Inhibition of Immune Response by Rapamycin, Can. J. Physiol. Pharmacol. 55: 48-51, 1977.
Morris et al., Identification of New Pharmacologic Action for an Old Compound, Med. Sci. Res. 17: 877-888, 1989.
Sehgal, S. N. and Chang, J. Y. Rapamycin: A New Immunosuppressive Macrolide. Transplantation and Immunology Letter (1990), VII: 12-14.
Calne, R. Y. et al., Rapamycin for Immunosuppression in Organ Allograting. The Lancet (Jul. 22, 1989), p. 227.
Carpenter, Immunosuppression in Organ Transplantation, New England J. of Med. 322: 1224-1226, 1990.
Vezina, C., Kudeiski, A. and Sehgal, S. N., Rapamycin (AY-22, 989). A New Anti-Fungal Antibiotic: I. Taxonomy of the Producing Streptomycete and Isolation of the Active Principle, J. Antibiotics (1975), 28:721-726.
Sehgal, S. N., Baker, H. and Vezina, C., Rapamycin (AY-22, 989). A New Antifungal Antibiotic: II. Fermation, Isolation and Characterization, J. Antibiotics (1975), 28:727-732.
Staruch et al., FK 506 and Rapamycin Inhibit Murine T-cell Activation Through Different Mechanisms, FASEB Journal, vol. 3, Abstract No. 3411, 1989.
Dumont et al., Rapamycin Blocks the Immunosuppressive Effect of FK506 But Not That of Cyclosporin A, FASEB Journal, vol. 3, Abstract No. 5256, 1989.
Kulkarni, P. S., Bhattacherjee, P., Eakins, K. E. and Srinivasan, B. D., Anti-Inflammatory Effects of Betamethasone Phosphate Dexamethasone Phosphate and Indomethacin on Rabbit Ocular Inflammation Induced by Bovine Serum Albumin, Current Eye Res. (1981), 1(1) :43-47.
Kulkarni, et al., Comparative In Vivo Inhibitory Effects of Non-Steroidal In A Non-Steroidal Anti-Inflammatory Agent on Prostaglandin Synthesis in Ocular Tissues, Prostaglandin Synthesis 103: 103-106, 1985.
De Vries et al., Cyclosporin and the Treatment of Severe Chronic Idiopathic Uveitis, Brit. J. Ophthal. 74: 344-349, 1990.
Sears, M. L., Aphakic Cystoid Macular Edema. The Pharmacology of Ocular Trauma. Surv. Ophthalmology (1984), 28: 525-534.
Nussenblatt, R. B., Palestine, A. G., and Chan, C-C. Cyclosporin A Therapy in the Treatment of Intraocular Inflammatory Disease Resistant to Systemic Systemic Corticosteroids and Cytotoxin Agents. Am. J. Ophthal. (1983), 96(3): 275-282.
Nussenblatt, R. B., Palestine, A. G., Rook, A. H., Scher, I., Wacker, W. B. and Gery, I. Treatment of Intraocular Inflammatory Disease with Cyclosporin A, The Lancet (1983), 2:235-238.
Bhattacherjee, P., William, R. E. and Eakins, K. E. An Evaluation of Ocular Inflammation Following the Injection of Bacterial Endotoxin into the Rat Foot Pad. Invest. Ophthalmol. and Vis. Sci. (1983), 24: 196-202.
Kulkarni, P. and Srinivasan, B. D. Ocular Inflammation: A Pharmacological Model, Trends in Pharmacological Sciences, (1987), 8(10) : 375-377.
Chan, C-C, Caspi, R., Mochizuki, M. et al. Cyclosporine and Dexamethasone Inhibit MHC Class I Antigens and IL-2 Receptor Expression in Experimental Autoimmune Uveitis, Immunological Invest. (1987), 16(4):319-331.
Kulkarni, P. S. and Srinivasan, B. D. Non-Steroidal Anti-Inflammatory Drugs in Ocular Inflammatory Conditions. Lewis, A. and Furst, D. E., eds., New York and Basel, Marcel Dekker, Inc., (1986), pp. 107-155.
Issekutz, T. B. Effects of Anti-Inflammatory Agents on Lymphocyte Migration Stimulated by the Interferons, Tumor Necrosis Factor and Cutaneous Inflammation, Int. J. Immunopharmacol. (1989), 11(7):725-732.
Masferrer, J. L., Zweifel, B. S., Seibert, K. and Needlemen, P. Selective Regulation of Cellular Cyclooxygenase by Dexamethasone and Endotoxin in Mice, J. Clin. Invest. (1990), 86: 1375-1379.
Flower, R. J. and Blackwell, G. J. Anti-Inflammatory Steroids Induce Biosynthesis of a Phospholipase A.sub.2 Inhibitor Which Prevents Prostaglandin Generation. Nature (1979), 278: 456-459.
Borel, J. F. Comparative Study In Vitro and In Vivo Drug Effects On Cell Mediated Cytotoxicity. Immunology (1976), 31:631-641.
Guo, A. Ohia, E., Xu, J., Bhattacherjee, P. and Kulkarni, P. S. Effects on Anti-Inflammatory and Immunosuppressive Drugs on the Heterolamellar Corneal Transplantation in Rabbits, Current Eye Res. (1990), 9(8): 749-757.
White, D. J. G. Cyclosporin A. Clinical Pharmacology and Therapeutic Potential, Drugs (1982), 24: 322-334.
Bradford, M. M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein . . . Anal. Biochem. (1976), 72:248-254.
Sedmak, J. J. and Grossberg, S. E. A Rapid and Versatile Assay for Protein Using Coomassie Brilliant Blue, Anal. Biochem. (1977), 79-544-552.
Bradley, et al. Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content With an Enzyme Marker. J. Invest. Dermatology (1982), 78:206-209.
EP Search Report for EP 92 11 2716 Collier et al., Current Opinion in Immunol. 2(6):854-858 (1990).
Smith Lang et al., FASEB 6(4):A1048 (1992) Thomson et al., Autoimmunity 12(4):303-313 (1992).

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