N-Cyano-N'-alkynyl-N"-2-mercaptoethylguanidines

Details N-Cyano-N'-alkynyl-N"-2-mercaptoethylguanidines N-Cyano-N'-alkynyl-N"-2-mercaptoethylguanidines

1978-05-18

1979-06-12

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260564H, C07C12508, C07C12908

Patent

active

041580133

ABSTRACT:
Anti-ulcer agents of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive, are prepared by reacting a compound of the formula ##STR2## wherein X is a conventional leaving group, preferably in the form of its acid addition salt, with a compound of the formula ##STR3## wherein R.sup.1 is as defined above. The intermediates of Formula III may be prepared by reacting a cysteamine salt with an isothiourea of the formula ##STR4## wherein R.sup.1 is as described above, in the presence of a base.

REFERENCES:
patent: 2697727 (1954-12-01), Kaiser
patent: 4013678 (1977-03-01), Brown et al.
patent: 4093621 (1978-06-01), Brown et al.

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