Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-06-18
1999-02-02
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514561, 514629, 514815, A61K 3119, A61K 31195, A61K 3116
Patent
active
RE0360805
ABSTRACT:
A method is provided for inhibiting the .gamma. to .beta.-globin switching in subjects afflicted with .beta.-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing butyrate, .alpha.-amino-n-butyric variations thereof,.!. isobutyramide into the bloodstream of the subject prior to natural completion of the switching process.
REFERENCES:
patent: 4482571 (1984-11-01), Abraham
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4822821 (1989-04-01), Perrine
Constantoulakis P. et al., 1988. "Alpha-amino-n-butyric Acid Stimulates Fetal Hemoglobin in the Adult". Blood 72: 1961-67.
Daniel P., et al., 1989. "Pharmacokinetic Study of Butyric Acid In Vivo as Sodium and Arginine Butyrate Salts". Clin.Chim. Acta 181: 255-263.
Karlsson, S. and Nienhuis, A.E., 1985. "Developmental Regulation of Human Globin Genes". Annu.Rev.Biochem. 54: 1071-1108.
Miller, A.A. et al., 1987. "Clinical Pharmacology of Sodium Butyrate Ion in Patients with Acute Leukemia". Eur.J.Cancer Clin. Oncol. 23: 1283-1287.
Murata et al., 1988. "EDF Initiates the Terminal Differentiation of Friend Leukemia Cells, Inducing de novo Hemoglobin Synthesis ", J. Ferbnt. Technol. 66(5): 501-507.
Noguchi et al., 1988. "Levels of Fetal Hemoglobin Necessary for Treatment of Sickle Cell Disease". N.Eng.J.Med. 318: 96-99.
Perrine, S.P. et al., 1989. "Butyrate Analogs Modulate Globin Gene Expression in Human and Ovine Erythroid Cells", Prog.Clin.Biol.Res 1989, 316B pp. 341-350.
Perrine, S.P. et al., 1989. "Butyric Acid Modulates Developmental Globin Gene Switching in Man and Sheep". Adv.Exp.Med.Biol. 271: 177-183.
Perrine, S.P. et al., Jul. 1989. "Sodium Butyrate Enhances Fetal Globin Gene Expression in Erythroid Progenitors of Patients with Hb SS and Beta-Thalassemia", Blood 74(1): 454-459.
Perrine, S.P. et al., Nov. 1988. "Butyrate Infusions in the Ovine Fetus Delay the Biological Clock for Globin Gene Switching", Proc.Natl.Acad.Sci.USA 85:8540-8542.
Perrine, S.P. et al., 1987. "Inhibition of Fetal Globin Gene Swtiching In Vivo in Human and Ovine Fetuses", Alan R. Liss, Inc.: Developmental Control of Globin Gene Expression 545-554.
Perrine, S.P. et al., 1987. "Butryric Acid Analogs Augment Gamma-Globin Gene Expression in in Neonatal Erythroid Progenitors", Biochem. Biophys. Res. Commun. 148(2): 694-700.
Perrine, S.P. et al., 1985. "Delay in the Fetal Globin Switch in Infants of Diabetic Mothers". N. Engl.J.Med. 312: 334-338.
Schechter, A.N. and C.T. Noguchi, 1979. "Inhibition of Sickle Hemoglobin Gelation by Peptides". In: Development of Therapeutic Agents for Sickle Cell Disease, eds. J. Rosa, Y. Beuzard and J. hercules, North-Holland Publishing Company, Amsterdam-New York-Oxford.
Tsuji et al., 1988. Structural and Biological Identity of Recombinant EDF (Erythroid Differentiation Factor) with Natural EDF. Agric. Biol. Chem. 52(9): 2143-2148.
Wood, W.G. et al., 1980. HbF Synthesis in Sickle Cell Anemia: A Comparison of Saudi Arab Cases with Those of African Origin. Br.J.Haematol. 45: 432-445.
S.P. Perrine et al., "Control of the Fetal Globin Switch In Vitro", J. Cell. Biochem., Supp. 10D, 1986, p. 40 (1986).
S.P. Perrine et al., "Investigation of Developmental Globin Gene Switching In Infants Of Diabetic Mothers", in Molecular Approaches To Developmental Biology, R.A. Firtel and E.H. DAvidson Eds., pp. 501-508 (1987).
S.P. Perrine et al., "Butyric Acid Modulates Developmental Globin Gene Switching In Man And Sheep", in Molecular Biology of Erythropoiesis J.L. Ascensao et al. Ed., pp. 177-183 (Jun. 1989).
Children's Hospital Medical Center of Northern California
Haley, Jr. James F.
Pierri Margaret A.
Spivack Phyllis G.
LandOfFree
Method for augmenting fetal hemoglobin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for augmenting fetal hemoglobin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for augmenting fetal hemoglobin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1106592