Process for the preparation of 4-fluorothiophenol

Details Process for the preparation of 4-fluorothiophenol Process for the preparation of 4-fluorothiophenol

1995-06-01

1997-08-19

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

C07C31902, C07C31914

Patent

active

056590881

ABSTRACT:
4-Fluorothiophenol is obtained in outstanding purifies and yields if 4-fluorobenzenesulphonyl chloride is reacted with sodium hydrogen sulphite solution to give a solution of sodium 4-fluorobenzenesulphinate, this solution is reduced with sulphur dioxide to give 4,4'-difluorodiphenyl disulphide and finally this is reacted with sodium borohydride in a water-miscible inert organic solvent to give 4-fluorothiophenol (sodium salt). Free 4-fluorothiophenol can be isolated from the sodium salt solution by acidification.

REFERENCES:
patent: 4209469 (1980-06-01), Thies et al.
Chemical Abstracts, vol. 51, N. 22, Abstract No. 17793 (d), (1957).
A. Ookawa, et al., Synthetic Communications, vol. 16, No. 7, pp. 819-825, (1986).
Chem. Ber., vol. 86, p. 179 (1953).
A. Nose, et al., Chem. Pharm. Bull., vol. 35, pp. 1770-1776 (1987).

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