Method for preparing esters of halonicotinic acids

Details Method for preparing esters of halonicotinic acids Method for preparing esters of halonicotinic acids

1994-10-25

1997-08-19

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21330

Patent

active

056590423

ABSTRACT:
The present invention provides a method of preparation of ethyl 6-halonicotinate, wherein said halo is chloro or iodo, which comprises reacting the 6-halonicotinic acid with triethyl orthoacetate, to yield the ethyl-6-halonicotinate.

REFERENCES:
patent: 4576629 (1986-03-01), Morland et al.
patent: 5023341 (1991-06-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
Yamanaka et al, Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride, Chemical Pharmaceutical Bulletin, 36(6) 2244-2247 (1988).
Trujillo et al, Facile Esterification of Sulfonic Acids and Carboxylic Acids with Triethylorthoacetate, Tetrahedron Letters, vol. 34, No. 46, pp. 7355-7358, 1993.
March, Advanced Organic Chemistry: Reactions, Mechanism, and Structure, 1968 by Mcgraw-Hill Inc. p. 21. 1968.

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