Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-03-21
1997-08-19
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514554, 514570, 514572, 514573, 514621, 514623, 514661, 514703, A61K 3122
Patent
active
056589476
ABSTRACT:
A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor. Betulinic acid is obtained by the steps of preparing an extract from the stem bark of Ziziphus mauritiana to mediate selective cytotoxic profile against human melanoma in the subject panel of human cancer cell lines, conducting a bioassay-directed fractionation based on the profile of biological activity using cultured human melanoma cells as the monitor, and obtaining betulinic acid.
REFERENCES:
patent: 5468888 (1995-11-01), Bouboutou et al.
Derwent Abstracts 89-204083/28, "Carcinostatics Containing Betulin Derivatives" Dec. 1987.
Chemical Abstracts 116:277, "Sterol and Triterpene Derivatives From Plants Inhibit the Effects of a Tumor Promoter" 1991.
Chemical Abstracts 112:125164, "Content of Betulin and Betulinic Acid, Antitumor Agents of Zizyphus Species" 1989.
DasGupta Tapas K.
Pezzuto John M.
Board of Trustees of the University of Illinois
Krass Frederick
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